NFL 2021: AFC South team-by-team predictions, best bets, odds and picks

The AFC South is littered with both star players and storylines across the board, and with so many questions heading into the season, we've got the best free NFL betting picks for the Texans, Colts, Jaguars and Titans ahead of NFL Week 1 in 2021.

A division that may not appeal to neutrals on paper, the AFC South could become one of the most exciting in the league with number one draft pick Trevor Lawrence headlining the show after the Jaguars finished 2020 with a 1-15 record.

Get the best NFL betting picks all season long at Dimers.com. Otherwise, let our advanced predictive analytics models do the hard work for you by visiting the Quick Picks page

Here are the NFL Futures bets we're throwing down for the AFC South ⏬

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Houston Texans

NFL Week 1 Matchup: Jaguars vs. Texans

Super Bowl 2021 Win Probability: 0.5%

Super Bowl 2021 Odds: +30000 (BetMGM)

The Texans are going to be bad, like, really bad!

With Deshaun Watson not likely to play this season, it could become very grim for the Houston team, and the possibility of them finishing with the worst record is a very real chance, with great odds on offer, too!

Dimers' Suggested Bet:
Worst regular season record (+250)

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Indianapolis Colts

NFL Week 1 Matchup: Seahawks vs. Colts

Super Bowl 2021 Win Probability: 3.1%

Super Bowl 2021 Odds: +2500 (BetMGM)

The Colts finished last season with a solid 11-5 record, seeing them finish in second place in the division. Both the Colts and Titans (who finished top) ended up with the same number of wins and losses in 2020.

But as we head towards Week 1 of 2021 NFL season, we've got the Titans going one step further this year and topping the AFC South.

Dimers' Suggested Bet:
Colts to win the AFC South (+125)

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Jacksonville Jaguars

NFL Week 1 Matchup: Jaguars vs. Texans

Super Bowl 2021 Win Probability: 1.0%

Super Bowl 2021 Odds: +12500 (BetMGM)

Jags fans didn't have a lot to celebrate last season, at least until they secured the number one pick and rights to taking Trevor Lawrence from the Clemson Tigers.

With the great white hope now officially playing at TIAA Bank Field, we loved reading there were odds of +300 available for him to take out the Offensive Rookie of the Year award for 2021.

Dimers' Suggested Bet:
Lawrence to win Offensive ROTY (+300)

MORE: NFL Week 1 Picks, Predictions and Odds
MORE: NFL Week 1 Most Likely Touchdown Scorers

Tennessee Titans

NFL Week 1 Matchup: Cardinals vs Titans

Super Bowl 2021 Win Probability: 2.7%

Super Bowl 2021 Odds: +2800 (DraftKings)

As mentioned above, the Titans finished last season at the top of the AFC South, but instead of placing a bet on the team this time around, we're going for a Futures player prop.

Derrick Henry is - as we all know - an absolute freak, and after rushing for a ridiculous 2,027 yards last season, we're loving the OVER when it comes to his 1550.5 rushing yards line this season! With 58 career TDs, Henry will be looking to make it to at least 59 touchdowns in NFL Week 1.

If you're feeling extra confident in King Henry's potential this season, you could do much worse than betting him to lead the league in rush yards at +450.

Dimers' Suggested Bets:
Derrick Henry OVER 1550.5 rush yards (-110)
Derrick Henry: Most rushing yards (+450)

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NFL divisional betting previews:

AFC East Preview | AFC North Preview

AFC South Preview | AFC West Preview

NFC East Preview | NFC North Preview

NFC South Preview | NFC West Preview