Yankees vs. Pirates Prediction: Yankees Predicted to Win Friday's MLB Matchup [4/4/2025]

The Pittsburgh Pirates will take on the New York Yankees in MLB action at PNC Park on Friday, beginning at 4:12PM ET.

The Pirates will have Mitch Keller (1-0, 1.50 ERA) as their starting pitcher, up against Max Fried (0-0, 3.86 ERA) for the Yankees.

Based on updated simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Yankees as the most likely winner of today's game.

"Employing the latest data, our experts simulated Friday's NY Yankees-Pittsburgh game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"After computing the latest updates and thousands of other inputs, we predict the Yankees' chance of winning is 58%, while the Pirates' is 42%."

For expanded analysis of Friday's matchup, including best bets and picks, visit our interactive Yankees vs. Pirates predictions page.

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Yankees vs. Yankees Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and statistical analysis, we have simulated the result of Friday's MLB game between the Yankees and Pirates 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Yankees a 58% chance of defeating the Pirates.

According to our model, the Pirates (+1.5) have a 55% chance of covering the run line, while the 7.5-run over/under has a 53% chance of going over.

Pre-Game Probabilities

Last Updated: 8:28PM, Apr 4

Moneyline

Over / Under

Run Line

Yankees

Win %

59%

41%

-174

+150

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Pirates

Yankees NYY

-174

Win %

59%

41%

See Matchup

Pirates PIT

+150

Max Fried 0-0, 3.86 ERA

Mitch Keller 1-0, 1.50 ERA

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Yankees vs. Pirates Odds [4/4/2025]

We have researched the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

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Yankees vs. Pirates Picks and Best Bets

Our model's biggest edge in today's Yankees vs. Pirates matchup is on the total.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the free picks featured below.

Yankees vs. Pirates Game-Day Updates and Essential Details

Friday's MLB game between the Pirates and Yankees at PNC Park is scheduled to begin at 4:12PM ET.

• Who: New York Yankees vs. Pittsburgh Pirates
• Date: Friday, April 4, 2025
• Time: 4:12PM ET/1:12PM PT
• Venue: PNC Park

Dimers.com's comprehensive preview of Friday's Yankees vs. Pirates matchup includes our prediction, picks and the latest betting odds.

Before making any NY Yankees vs. Pittsburgh picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Yankees, with a 58% win probability, will likely beat the Pirates on Friday.

AI and automation have enhanced this article to quickly deliver accurate Yankees vs. Pirates insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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