Yankees vs. Guardians Prediction: Yankees Predicted to Win Wednesday's MLB Matchup [4/23/2025]

MLB action continues on Wednesday at 1:10PM ET as the New York Yankees lock horns with the Cleveland Guardians at Progressive Field.

Luis L. Ortiz (2-2, 5.48 ERA) will be the starting pitcher for the Guardians, up against Carlos Rodón (2-3, 4.34 ERA) for the Yankees.

Based on updated simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Yankees as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's NY Yankees-Cleveland game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Yankees' chance of winning at 56%, with the Guardians at 44%."

For expanded analysis of Wednesday's matchup, including best bets and picks, visit our interactive Yankees vs. Guardians predictions page.

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Guardians vs. Yankees Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data analysis, we have simulated the result of Wednesday's MLB game between the Yankees and Guardians 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Yankees a 56% chance of beating the Guardians.

According to our model, the Guardians (+1.5) have a 57% chance of covering the run line, while the 8.5-run over/under has a 54% chance of staying under.

Pre-Game Probabilities

Last Updated: 5:28PM, Apr 23

Moneyline

Over / Under

Run Line

Yankees

Win %

57%

43%

-162

+145

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See Matchup

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Guardians

Yankees NYY

-162

Win %

57%

43%

See Matchup

Guardians CLE

+145

Carlos Rodón 2-3, 4.35 ERA

Luis Ortiz 2-2, 5.48 ERA

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Yankees vs. Guardians Odds [4/23/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Yankees vs. Guardians Picks and Best Bets

Our model's strongest edge in today's Yankees vs. Guardians matchup is on the over/under.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the latest predictions featured below.

Yankees vs. Guardians Game-Day Updates and Essential Details

Wednesday's MLB matchup between the Guardians and Yankees at Progressive Field is scheduled to commence at 1:10PM ET.

• Who: New York Yankees vs. Cleveland Guardians
• Date: Wednesday, April 23, 2025
• Time: 1:10PM ET/10:10AM PT
• Venue: Progressive Field

Dimers.com's comprehensive preview of Wednesday's Yankees vs. Guardians matchup includes our prediction, picks and the latest betting odds.

Before making any NY Yankees vs. Cleveland picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Yankees, with a 56% win probability, will likely beat the Guardians on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Yankees vs. Guardians insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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