Mets vs. Astros Prediction: Houston Predicted to Win MLB Opening Day Matchup [3/27/2025]

MLB Opening Day action continues on Thursday at 4:10PM ET as the New York Mets take on the Houston Astros at Daikin Park.

The Astros will have Framber Valdez (0-0, 0.00 ERA) as their starting pitcher, while the Mets are going with Clay Holmes (0-0, 0.00 ERA).

Based on the latest simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Astros as the most likely winner of today's game.

"Using the latest data, our experts simulated Thursday's NY Mets-Houston game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Taking into account recent updates and various additional inputs, we forecast the Astros with a win probability of 57% and the Mets with 43%."

For further insights into Thursday's matchup, including best bets and picks, visit our interactive Mets vs. Astros predictions page.

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Mets vs. Mets Prediction: Who Will Win on MLB Opening Day?

Using innovative machine learning and data, we have simulated the result of Thursday's MLB matchup between the Mets and Astros 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Astros a 57% chance of defeating the Mets.

According to our model, the 8-run over/under has a 53% chance of staying under.

Pre-Game Probabilities

Last Updated: 8:28PM, Mar 27

Moneyline

Over / Under

Run Line

Mets

Win %

44%

56%

+102

-114

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See Matchup

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Astros

Mets NYM

+102

Win %

44%

56%

See Matchup

Astros HOU

-114

Clay Holmes 0-0, 0.00 ERA

Framber Valdez 0-0, 0.00 ERA

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Mets vs. Astros Odds [3/27/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Mets vs. Astros Picks and Best Bets

Our model's biggest edge in today's Mets vs. Astros matchup is on the moneyline.

Our expert predictions, matched against the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Best Bets Today

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Mets vs. Astros Game-Day Updates and Essential Details

Thursday's MLB action between the Astros and Mets at Daikin Park is scheduled to start at 4:10PM ET.

• Who: New York Mets vs. Houston Astros
• Date: Thursday, March 27, 2025
• Time: 4:10PM ET/1:10PM PT
• Venue: Daikin Park

Dimers.com's comprehensive preview of Thursday's Mets vs. Astros matchup includes our prediction, picks and the latest betting odds.

Before making any NY Mets vs. Houston picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Astros, with a 57% win probability, will likely beat the Mets on Thursday.

AI and automation have enhanced this article to quickly deliver accurate Mets vs. Astros insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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