Patriots vs. 49ers Prediction: San Francisco Predicted to Win Following Latest Data Analysis for NFL Week 4 [2024]

NFL Week 4 action continues on Sunday at 4:05PM ET as the New England Patriots take on the favored San Francisco 49ers at Levi's Stadium.

Based on the latest simulation results, Dimers' advanced NFL model (see Dimers Pro for full access) predicts the 49ers as the most likely winner of the game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Patriots-49ers game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the 49ers with a win probability of 84%, while the Patriots have 16%."

Patriots vs. 49ers Game-Day Updates and Essential Details

The NFL Week 4 game between the 49ers and Patriots at Levi's Stadium is scheduled to begin at 4:05PM ET.

• Who: New England Patriots vs. San Francisco 49ers
• Date: Sunday, September 29, 2024
• Time: 4:05PM ET/1:05PM PT
• Venue: Levi's Stadium
• Tickets: Get tickets for the game on Ticketmaster
• Merchandise: Buy 49ers and Patriots gear at Fanatics

Dimers.com's comprehensive preview of Sunday's Patriots vs. 49ers matchup includes our prediction, picks and the latest betting odds.

Before making any 49ers vs. Patriots picks, be sure to check out the latest NFL predictions and betting advice from Dimers Pro.

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Patriots vs. 49ers Predictions

Using innovative machine learning and statistical analysis, we have simulated the outcome of Sunday's NFL matchup between the Patriots and 49ers 10,000 times as part of our NFL predictions coverage.

Our independent predictive model gives the 49ers an 84% chance of defeating the Patriots in Week 4 of the NFL season. Our predicted final score has the 49ers winning 24-15.

According to our model, the Patriots (+10) have a 53% chance of covering the spread, while the over/under total of 39.5 points has a 54% chance of going over.

Patriots vs. 49ers Odds

We have sourced the best betting odds in America for this game, which are listed here:

Bet Type	Patriots	49ers
Spread	+10 (-105)	-10 (-110)
Moneyline	+420	-520
Total	o39.5 (-110)	u39.5 (-108)

All odds are correct at the time of publication and are subject to change.

Patriots vs. 49ers Picks

Our model's biggest edge in the Patriots vs. 49ers matchup is on the total.

Our expert predictions, matched against the current odds, reveal the best NFL picks for every game throughout the season.

Full access to our picks, including this one, is available via Dimers Pro.

Patriots vs. 49ers TD Scorers

Who will score an anytime touchdown in Patriots vs. 49ers?

According to our model, San Francisco's Jordan Mason is most likely to score the first touchdown in Patriots vs. 49ers.

Our projections give Mason a 14.9% chance of scoring the first TD at Levi's Stadium, while the 49ers RB is a 52.5% chance of registering an anytime touchdown.

First Touchdown Scorer Predictions

New England Patriots

Player	First TD Probability
Rhamondre Stevenson	10.3%
Antonio Gibson	5.2%
Hunter Henry	4.3%

San Francisco 49ers

Player	First TD Probability
Jordan Mason	14.9%
Deebo Samuel	11.2%
Brandon Aiyuk	10.8%

Anytime Touchdown Scorer Predictions

New England Patriots

Player	Anytime TD Probability
Rhamondre Stevenson	41.0%
Antonio Gibson	22.0%
Hunter Henry	19.4%

San Francisco 49ers

Player	Anytime TD Probability
Jordan Mason	52.5%
Deebo Samuel	41.7%
Brandon Aiyuk	40.6%

Patriots vs 49ers Player Props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Patriots and 49ers. For detailed projections, join Dimers Pro.

Already a Dimers Pro member? Head to our Patriots-49ers page now to access every player prop projection.

Patriots vs. 49ers Quarterbacks

Of the starting quarterbacks, the Patriots' Jacoby Brissett is projected to throw for fewer yards than the 49ers' Brock Purdy.

Patriots Rushing

Rhamondre Stevenson, Antonio Gibson and Jacoby Brissett are projected to be the leading rushers for the Patriots.

Player	Position
Rhamondre Stevenson	RB
Antonio Gibson	RB
Jacoby Brissett	QB

49ers Rushing

Jordan Mason, Isaac Guerendo and Brock Purdy are expected to lead the 49ers in rushing yards.

Player	Position
Jordan Mason	RB
Isaac Guerendo	RB
Brock Purdy	QB

Patriots Receiving

Hunter Henry, DeMario Douglas, K.J. Osborn, Rhamondre Stevenson and Ja'Lynn Polk are projected to top the receiving yards for the Patriots.

Player	Position
Hunter Henry	TE
DeMario Douglas	WR
K.J. Osborn	WR
Rhamondre Stevenson	RB
Ja'Lynn Polk	WR

49ers Receiving

Brandon Aiyuk, Deebo Samuel, George Kittle, Jauan Jennings and Kyle Juszczyk are projected to lead the 49ers in receiving yards.

Player	Position
Brandon Aiyuk	WR
Deebo Samuel	WR
George Kittle	TE
Jauan Jennings	WR
Kyle Juszczyk	WR

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Conclusion

We predict the 49ers, with an 84% win probability, will likely beat the Patriots in Week 4 of the NFL season.

AI and automation have enhanced this article to quickly deliver accurate Patriots vs. 49ers insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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