New England Patriots vs. Buffalo Bills Early Predictions for NFL Week 16: Odds, Picks and Preview [2024]

The Buffalo Bills and New England Patriots are scheduled to meet in Week 16 of the NFL season at Highmark Stadium on Sunday, December 22, 2024, with kickoff set for 1:00PM ET.

Early simulation results from Dimers' advanced NFL model project the Bills as the most likely winner of this game.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Patriots vs. Bills predictions page.

Patriots vs. Bills Week 16 Details

The NFL Week 16 game between the Bills and Patriots at Highmark Stadium is scheduled for December 22, 2024.

• Who: New England Patriots vs. Buffalo Bills
• Date: Sunday, December 22, 2024
• Time: 1:00PM ET/10:00AM PT
• Venue: Highmark Stadium

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Patriots vs. Bills Opening Odds

We've sourced the best betting odds across America for this Week 16 game, detailed below:

• Spread: Patriots +8.5 (-110), Bills -8.5 (-110)
• Moneyline: Patriots +320, Bills -410
• Total: Over/Under 44.5 (-110/-110)

New England vs. Buffalo Early Predictions

Leveraging trusted machine learning and analysis, we have simulated the Patriots vs. Bills game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight Up Win Probabilities: Patriots 23%, Bills 77%
• Predicted Final Score: Patriots 18-25 Bills
• Spread: Patriots (+8.5) 50%, Bills (-8.5) 50%
• Total Points (44.5): Over 50%, Under 50%

As of December 15, 2024, these Patriots-Bills predictions reflect the latest data and insights available.

Conclusion

We predict the Bills, with a 77% win probability, will likely beat the Patriots in Week 16 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Patriots vs. Bills matchup, with human oversight maintaining high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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