Nationals vs. Orioles Prediction and Odds - Jun 21, 2022

The Baltimore Orioles square off with the Washington Nationals in MLB action at Oriole Park at Camden Yards on Tuesday, commencing at 7:05PM ET.

Jordan Lyles (4-5, 5.10 ERA) will get the ball for the Orioles, pitting him against Erick Fedde (4-5, 4.88 ERA) for the Nationals.

Dimers' best betting picks for Nationals vs. Orioles, plus game predictions and best odds, are featured in this article.

Who will win Nationals vs. Orioles?

Using trusted computer power and data, Dimers.com has simulated Tuesday's Nationals-Orioles MLB matchup 10,000 times.

Dimers' renowned predictive analytics model, DimersBOT, currently gives the Orioles a 53% chance of defeating the Nationals.

More: Nationals vs. Orioles Simulated 10,000 Times

Nationals vs. Orioles Game Odds

• Run Line: Orioles -1.5 (+150), Nationals +1.5 (-172)
• Moneyline: Orioles -126, Nationals +110
• Total: Over/Under 9.5 (+100/-120)

Run Line, Moneyline and Over/Under

The Orioles are -1.5 favorites versus the Nationals, with +150 at DraftKings Sportsbook the best odds currently available.

For the underdog Nationals (+1.5) to cover the run line, FanDuel Sportsbook has the best odds currently on offer at -172.

FanDuel Sportsbook currently has the best moneyline odds for the Orioles at -126. That means you can risk $126 to win $100, for a total payout of $226, if they get the W.

On the other hand, BetMGM currently has the best moneyline odds for the Nationals at +110, where you can bet $100 to profit $110, earning a total payout of $210, if they win.

The Over/Under sits at 9.5 with BetMGM, which currently has the best odds for the Over at +100, as well as the best odds for the Under at -120.

As always, check out the sportsbooks you can bet with in your state for the best MLB odds and lines.

According to DimersBOT, the Nationals (+1.5) are a 63% chance of covering the run line, while the 9.5-run Over/Under is a 52% chance of going Under.

More: Free Prop Picks

Best Bets for Nationals vs. Orioles

• Run Line: Nationals +1.5 @ -172 via FanDuel Sportsbook (63% probability)
• Moneyline: Nationals @ +110 via BetMGM
• Total: Over 9.5 @ +100 via BetMGM

Dimers' best bets are based on world-class modeling and betting intelligence to serve you the best possible plays every day of the year.

While the Orioles are more likely to win the game, according to DimersBOT, taking the Nationals moneyline is the best option due to the edge found when comparing our data-led probabilities to the betting odds currently on offer.

Taking advantage of the edges seen on Dimers is pivotal to achieving long-term profitability as a sports bettor.

Furthermore, despite the Under being more likely to hit on this occasion, Over 9.5 is our best bet owing to the better odds (+100) that are available from BetMGM.

Nationals vs. Orioles Prediction

Use our interactive widget below to see up-to-date Moneyline, Over/Under and Run Line probabilities and odds for Washington vs. Baltimore, and click or tap on See Matchup for more.

Dimers has full betting coverage of Tuesday's Nationals-Orioles matchup, including pregame predictions, free picks, and live win probabilities.

Remember, DimersBOT updates frequently, so keep an eye on this article for any changes to our betting insights ahead of Nationals vs. Orioles on Tuesday June 21, 2022.

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Nationals vs. Orioles 2022 Game Info

Tuesday's matchup between the Orioles and Nationals at Oriole Park at Camden Yards is scheduled to begin at 7:05PM ET.

• Who: Baltimore Orioles vs. Washington Nationals
• Date: Tuesday June 21, 2022
• Time: 7:05PM ET / 4:05PM PT
• Venue: Oriole Park at Camden Yards

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Want more MLB predictions like this?

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We use the power of predictive analytics to find edges in the markets so we can produce the most comprehensive MLB betting previews available. We're able to do this by comparing our in-house probabilities against the sportsbooks' odds (aka Vegas odds) the minute they go live.

So, get ahead of the game and beat the bookies today – it's only a click away.

While you're here, Dimers' Baseball Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities compared to the best odds to win the World Series.