Mount St. Mary's vs. Duke Prediction: Duke Predicted to Win March Madness First Round Matchup [3/21/2025]

March Madness action continues on Friday at 2:50PM ET as Mount St. Mary's squares off with Duke in college basketball action at Lenovo Center.

Based on the latest simulations, Dimers' proven college basketball model (see Dimers Pro for full access) predicts Duke as the most likely winner of today's game.

Check the latest March Madness bracket projections and 2025 NCAA Championship probabilities from our expert team.

"Employing the latest data, our experts simulated Friday's Mount St. Mary's-Duke game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"After computing the latest updates and thousands of other inputs, we predict Duke's chance of winning is 99%, while Mount St. Mary's' is 1%."

For expanded analysis of Friday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Mount St. Mary's vs. Duke predictions page.

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Mount St. Mary's vs. Duke Prediction: Who Will Win and Advance to the Second Round?

Using trusted machine learning and statistical analysis, we have simulated the outcome of Friday's NCAA Tournament matchup between Mount St. Mary's and Duke 10,000 times as part of our March Madness predictions coverage.

Our independent predictive model gives Duke a 99% chance of beating Mount St. Mary's. Our predicted final score has Duke winning 87-58.

According to our model, Mount St. Mary's (+32.5) has a 54% chance of covering the spread, while the 141.5-point over/under has a 55% chance of going over.

Mount St. Mary's vs. Duke March Madness Odds

We have researched the best March Madness odds in America for this First Round game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Boost your betting this month with the top March Madness betting sites and March Madness betting promos, sourced from top sportsbooks and DFS operators.

Mount St. Mary's vs. Duke Picks and Best Bets

Our model's biggest edge in today's Mount St. Mary's vs. Duke matchup is on the spread.

Our expert predictions, aligned with the best odds, reveal the best March Madness picks and March Madness best bets for every game throughout the tournament.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Mount St. Mary's vs. Duke Game-Day Updates and Essential Details

Friday's college basketball game between Duke and Mount St. Mary's at Lenovo Center is scheduled to begin at 2:50PM ET.

• Who: Mount St. Mary's vs. Duke
• Date: Friday, March 21, 2025
• Time: 2:50PM ET/11:50AM PT
• Venue: Lenovo Center
• March Madness Stage: First Round

Dimers.com's full preview of Friday's Mount St. Mary's vs. Duke matchup includes our prediction, picks and the latest betting odds.

Before making any Mount St. Mary's vs. Duke picks, be sure to check out the latest March Madness predictions and betting advice from Dimers Pro.

Key March Madness Guides and Insights

• Learn about NCAA Championship history and the lowest-seeded team to ever win March Madness
• Get answers to legal questions, including which states you can legally bet on college sports and the minimum age required to place a bet on March Madness
• A breakdown of March Madness futures bets and popular prop bets for the NCAA tournament
• Explore strategy with guides on identifying value bets during the tournament and betting on individual player awards like Tournament MVP
• Understand the tournament format, including how many games are played in March Madness and how venue locations impact teams when playing at neutral sites

Conclusion

We predict Duke, with a 99% win probability, will likely beat Mount St. Mary's on Friday.

AI and automation have enhanced this article to quickly deliver accurate Mount St. Mary's vs. Duke insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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