MLS Betting Tips: Saturday's Picks Include Chicago vs. Vancouver Play [3/22/2025]

MLS betting is back for another pulse-pounding slate on 3/22, and we're here to share our top picks for Saturday's soccer action.

Today's MLS best bets come from a range of matchups, including the Chicago vs. Vancouver game at 10:30PM ET, with this article updated throughout the day to highlight the most attractive upcoming games.

Featuring a standout moneyline play at 10:30PM ET, these picks are powered by cutting-edge simulations and machine learning.

For unlimited access to everything Dimers has to offer on Saturday, March 22, 2025—including our full set of MLS picks and best bets—check out Dimers Pro.

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List of MLS Betting Tips Tonight [3/22, Updated: 10:03PM ET]

After crunching the numbers and conducting thousands of simulations, our independent predictive analytics model has identified the best soccer bet for Saturday, March 22, 2025.

This is the only pick available for free users currently, with our full suite of MLSpredictions reserved for Dimers Pro users.

Vancouver ML (-120)

• Edge: 2.5%
• Probability: 57.1%
• Matchup: Chicago vs. Vancouver (10:30PM ET, Saturday)

Our model has pinpointed the next MLS betting opportunity tonight, which comes in the Chicago vs. Vancouver matchup. We recommend a bet on Vancouver ML at -120 odds, offering an edge of 2.5%.

Vancouver ML vs. Chicago

-120

Bet $25
Payout $45.82Bet $25, Payout $45.82

MLS Best Bets: Saturday, 3/22/2025

As of 10:03PM ET, here are the next MLS bets recommended by our model:

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Subscribing to Dimers Pro grants you unlimited access to today's best bets across all sports, powered by our advanced model.

Join Dimers Pro now to access these picks, along with a comprehensive range of props, trends and parlays for March 22, 2025.

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List of Upcoming MLS Games to Bet On [3/22/2025]

• Houston vs. Seattle (10:30PM ET, Saturday)
• Chicago vs. Vancouver (10:30PM ET, Saturday)
• San Diego FC vs. Austin (4:00PM ET, Sunday)

More About MLS

This article is part of our MLS best bets series.

For more MLS betting content, we have MLS betting news and the latest MLS Cup odds and predictions.

Conclusion

This article, enhanced by AI and automation, aims to deliver accurate MLS insights quickly, with human oversight ensuring high editorial quality. Our predictions are drawn from current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.