MLS Betting Tips: Saturday's Picks Include Colorado vs. San Jose Play [3/15/2025]

MLS betting is back for another pulse-pounding day on 3/15, and we're here to serve up our top picks for Saturday's soccer action.

Today's MLS best bets come from a range of matchups, including the Colorado vs. San Jose game at 10:30PM ET, with this article updated throughout the day to highlight the most attractive upcoming games.

Led by a standout moneyline play at 10:30PM ET, these picks are based on cutting-edge simulations and machine learning.

For unlimited access to everything Dimers has to offer on Saturday, March 15, 2025—including our full set of MLS picks and best bets—check out Dimers Pro.

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List of MLS Betting Tips Tonight [3/15, Updated: 10:03PM ET]

After diving deep into the numbers and conducting thousands of simulations, our famous predictive analytics model has figured out the best soccer bet for Saturday, March 15, 2025.

This is the only pick available for free users currently, with our full suite of MLSpredictions reserved for Dimers Pro users.

Colorado ML (+270)

• Edge: 3.8%
• Probability: 30.8%
• Matchup: Colorado vs. San Jose (10:30PM ET, Saturday)

Our model has pinpointed the next MLS betting opportunity tonight, which comes in the Colorado vs. San Jose matchup. We recommend a bet on the Colorado ML at +270 odds, offering an edge of 3.8%.

Colorado ML vs. San Jose

+270

Bet $25
Payout $92.50Bet $25, Payout $92.50

MLS Best Bets: Saturday, 3/15/2025

As of 10:03PM ET, here are the next MLS bets recommended by our model:

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Subscribing to Dimers Pro grants you unlimited access to today's best bets across all sports, powered by our advanced model.

Join Dimers Pro now to access these picks, along with a comprehensive range of props, trends and parlays for March 15, 2025.

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List of Upcoming MLS Games to Bet On [3/15/2025]

• Columbus vs. San Diego FC (10:30PM ET, Saturday)
• Colorado vs. San Jose (10:30PM ET, Saturday)
• Nashville vs. Philadelphia (2:25PM ET, Sunday)
• LA Galaxy vs. Portland (4:45PM ET, Sunday)
• Miami vs. Atlanta (7:00PM ET, Sunday)

More on MLS

This article is part of our MLS best bets series.

For more MLS betting content, we have MLS betting news and the latest MLS Cup odds and predictions.

Conclusion

This article, enhanced by AI and automation, aims to deliver accurate MLS insights quickly, with human oversight ensuring high editorial quality. Our predictions are based on current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.