Twins vs. Guardians Prediction: Cleveland Predicted to Win Tuesday's MLB Matchup [4/29/2025]

The Cleveland Guardians will square off with the Minnesota Twins in MLB action at Progressive Field on Tuesday, commencing at 6:10PM ET.

The Guardians will have Tanner Bibee (2-2, 5.19 ERA) as their starting pitcher, while the Twins are going with Chris Paddack (0-3, 6.45 ERA).

Based on updated simulations, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Guardians as the most likely winner of today's game.

"Our team has analyzed the latest data and conducted 10,000 simulations for Tuesday's Minnesota-Cleveland game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various factors, our prediction shows the Guardians with a win probability of 58%, compared to 42% for the Twins."

For a closer look at Tuesday's matchup, including best bets and picks, visit our interactive Twins vs. Guardians predictions page.

Get 20% off Dimers Pro With Code 20BASEBALL

Get Dimers Pro

Guardians vs. Twins Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data analysis, we have simulated the result of Tuesday's MLB matchup between the Twins and Guardians 10,000 times as part of our MLB predictions coverage.

Our famous predictive model gives the Guardians a 58% chance of defeating the Twins.

According to our model, the Twins (+1.5) have a 62% chance of covering the run line, while the 8-run over/under has a 54% chance of going over.

Twins vs. Guardians Odds [4/29/2025]

We have researched the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Twins vs. Guardians Picks and Best Bets

Our model's biggest edge in today's Twins vs. Guardians matchup is on the run line.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Unlock Every Twins-Guardians Pick

Get Dimers Pro

Calling Our Shot's Best Bets Video

Calling Our Shot produces daily MLB betting content, including the predictions featured below.

Twins vs. Guardians Game-Day Updates and Essential Details

Tuesday's MLB matchup between the Guardians and Twins at Progressive Field is scheduled to begin at 6:10PM ET.

• Who: Minnesota Twins vs. Cleveland Guardians
• Date: Tuesday, April 29, 2025
• Time: 6:10PM ET/3:10PM PT
• Venue: Progressive Field

Dimers.com's full preview of Tuesday's Twins vs. Guardians matchup includes our prediction, picks and the latest betting odds.

Before making any Minnesota vs. Cleveland picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
• Understand where sports odds come from and how they're applied to baseball matchups
• Learn how to use Dimers Futures to find long-term betting opportunities as the World Series draws closer
• Stay informed with where online sports betting is currently legal and which betting sites are safest to use
• Boost your success with strategies to win at sports betting and explore why MLB is one of the best leagues to bet on

Conclusion

We predict the Guardians, with a 58% win probability, will likely beat the Twins on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Twins vs. Guardians insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Keep up with the latest MLB news and MLB parlay picks throughout the season. Plus, our World Series odds provide the most accurate projections for the World Series, American League, National League and each division.