Twins vs. Guardians Prediction: Cleveland Predicted to Win Monday's MLB Matchup [4/28/2025]

The Cleveland Guardians will take on the Minnesota Twins in MLB action at Progressive Field on Monday, beginning at 6:10PM ET.

Gavin Williams (2-1, 4.15 ERA) will start for the Guardians, up against Bailey Ober (2-1, 5.04 ERA) for the Twins.

Based on updated simulations, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Guardians as the most likely winner of today's game.

"Our team has utilized the latest data to simulate Monday's Minnesota-Cleveland game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Incorporating recent updates and thousands of additional inputs, our prediction shows the Guardians are likely to win, with a probability of 56%, compared to the Twins' 44%."

For further insights into Monday's matchup, including best bets and picks, visit our interactive Twins vs. Guardians predictions page.

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Guardians vs. Twins Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and statistical analysis, we have simulated the outcome of Monday's MLB game between the Twins and Guardians 10,000 times as part of our MLB predictions coverage.

Our independent predictive model currently gives the Guardians a 56% chance of beating the Twins.

According to our model, the Twins (+1.5) have a 64% chance of covering the run line, while the over/under total of 8 runs has an equal 50-50 chance of hitting.

Pre-Game Probabilities

Last Updated: 10:28PM, Apr 28

Moneyline

Over / Under

Run Line

Twins

Win %

45%

55%

+110

-124

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Guardians

Twins MIN

+110

Win %

45%

55%

See Matchup

Guardians CLE

-124

Bailey Ober 2-1, 5.04 ERA

Gavin Williams 2-1, 4.15 ERA

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Twins vs. Guardians Odds [4/28/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

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Twins vs. Guardians Picks and Best Bets

Our model's biggest edge in today's Twins vs. Guardians matchup is on the moneyline.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

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Twins vs. Guardians Game-Day Updates and Essential Details

Monday's MLB action between the Guardians and Twins at Progressive Field is scheduled to start at 6:10PM ET.

• Who: Minnesota Twins vs. Cleveland Guardians
• Date: Monday, April 28, 2025
• Time: 6:10PM ET/3:10PM PT
• Venue: Progressive Field

Dimers.com's full preview of Monday's Twins vs. Guardians matchup includes our prediction, picks and the latest betting odds.

Before making any Minnesota vs. Cleveland picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Guardians, with a 56% win probability, will likely beat the Twins on Monday.

AI and automation have enhanced this article to quickly deliver accurate Twins vs. Guardians insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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