Brewers vs. Giants Prediction: San Francisco Predicted to Win Tuesday's MLB Matchup [4/22/2025]

The San Francisco Giants will face the Milwaukee Brewers in MLB action at Oracle Park on Tuesday, commencing at 9:45PM ET.

Jordan Hicks (1-2, 6.04 ERA) will get the ball for the Giants, while the Brewers have opted for Jose Quintana (2-0, 0.71 ERA).

Based on updated simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Giants as the most likely winner of today's game.

"Our team has analyzed the latest data and conducted 10,000 simulations for Tuesday's Milwaukee-San Francisco game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various factors, our prediction shows the Giants with a win probability of 56%, compared to 44% for the Brewers."

For expanded analysis of Tuesday's matchup, including best bets and picks, visit our interactive Brewers vs. Giants predictions page.

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Giants vs. Brewers Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data analysis, we have simulated the outcome of Tuesday's MLB matchup between the Brewers and Giants 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Giants a 56% chance of defeating the Brewers.

According to our model, the Brewers (+1.5) have a 63% chance of covering the run line, while the over/under total of 8 runs has a 53% chance of staying under.

Pre-Game Probabilities

Last Updated: 1:34AM, Apr 23

Moneyline

Over / Under

Run Line

Brewers

Win %

44%

56%

+130

-142

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Giants

Brewers MIL

+130

Win %

44%

56%

See Matchup

Giants SF

-142

Jose Quintana 2-0, 0.71 ERA

Jordan Hicks 1-2, 6.05 ERA

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Brewers vs. Giants Odds [4/22/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Brewers vs. Giants Picks and Best Bets

Our model's strongest edge in today's Brewers vs. Giants matchup is on the run line.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Brewers vs. Giants Game-Day Updates and Essential Details

Tuesday's MLB action between the Giants and Brewers at Oracle Park is scheduled to commence at 9:45PM ET.

• Who: Milwaukee Brewers vs. San Francisco Giants
• Date: Tuesday, April 22, 2025
• Time: 9:45PM ET/6:45PM PT
• Venue: Oracle Park

Dimers.com's full preview of Tuesday's Brewers vs. Giants matchup includes our prediction, picks and the latest betting odds.

Before making any Milwaukee vs. San Francisco picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Giants, with a 56% win probability, will likely beat the Brewers on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Brewers vs. Giants insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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