Brewers vs. Giants Prediction: San Francisco Predicted to Win Monday's MLB Matchup [4/21/2025]

MLB action continues on Monday at 9:45PM ET as the Milwaukee Brewers take on the San Francisco Giants at Oracle Park.

Robbie Ray (3-0, 4.19 ERA) will start for the Giants, pitting him against Quinn Priester (1-0, 0.90 ERA) for the Brewers.

Based on the latest simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) projects the Giants as the most likely winner of today's game.

"Our team has utilized the latest data to simulate Monday's Milwaukee-San Francisco game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Incorporating recent updates and thousands of additional inputs, our prediction shows the Giants are likely to win, with a probability of 55%, compared to the Brewers' 45%."

For expanded analysis of Monday's matchup, including best bets and picks, visit our interactive Brewers vs. Giants predictions page.

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Brewers vs. Brewers Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data, we have simulated the outcome of Monday's MLB matchup between the Brewers and Giants 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Giants a 55% chance of beating the Brewers.

According to our model, the Brewers (+1.5) have a 62% chance of covering the run line, while the 8-run over/under has a 53% chance of staying under.

Pre-Game Probabilities

Last Updated: 1:32AM, Apr 22

Moneyline

Over / Under

Run Line

Brewers

Win %

45%

55%

+116

-135

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Giants

Brewers MIL

+116

Win %

45%

55%

See Matchup

Giants SF

-135

Quinn Priester 1-0, 0.90 ERA

Robbie Ray 3-0, 4.19 ERA

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Brewers vs. Giants Odds [4/21/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Brewers vs. Giants Picks and Best Bets

Our model's strongest edge in today's Brewers vs. Giants matchup is on the run line.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Best Bets Video

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Brewers vs. Giants Game-Day Updates and Essential Details

Monday's MLB action between the Giants and Brewers at Oracle Park is scheduled to start at 9:45PM ET.

• Who: Milwaukee Brewers vs. San Francisco Giants
• Date: Monday, April 21, 2025
• Time: 9:45PM ET/6:45PM PT
• Venue: Oracle Park

Dimers.com's in-depth preview of Monday's Brewers vs. Giants matchup includes our prediction, picks and the latest betting odds.

Before making any Milwaukee vs. San Francisco picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Giants, with a 55% win probability, will likely beat the Brewers on Monday.

AI and automation have enhanced this article to quickly deliver accurate Brewers vs. Giants insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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