Michigan State vs. Purdue CFB Predictions and Odds - Nov 6, 2021

College Football Week 10 action continues on Saturday at 3:30 PM EDT as Michigan State takes on Purdue at Ross-Ade Stadium.

Dimers' top betting picks for Michigan State vs. Purdue, as well as game predictions and best odds, are detailed in this article.

Who will win Michigan State vs. Purdue?

Using cutting-edge machine learning and data, Dimers.com has simulated Saturday's Michigan State-Purdue matchup 10,000 times.

Dimers' leading predictive analytics model, DimersBOT, gives Michigan State a 52% chance of getting the W against Purdue.

MORE: Full betting guide for Michigan State vs. Purdue

Michigan State vs. Purdue Point Spread, Moneyline and Over/Under

Purdue is the +2.5 underdog at home to Michigan State, with -105 at DraftKings Sportsbook the best odds available.

For the favored Michigan State (-2.5) to cover the spread, Caesars Sportsbook has the best odds on offer at -110.

DraftKings Sportsbook has the best moneyline odds for Purdue at +125. That means you can throw down $100 to profit $125, earning a total payout of $225, if it wins.

On the other hand, PointsBet has the best moneyline odds for Michigan State at -135, where you can risk $135 to win $100, for a total payout of $235, if it comes out on top.

The Over/Under for total points scored sits at 53.5 with FanDuel Sportsbook, which has the best odds for the Over at -106, while Caesars Sportsbook has the best odds for the Under at -110.

As always, check out the sportsbooks you have access to in your state for the best College Football odds and lines.

According to DimersBOT, Purdue (+2.5) is a 54% chance of covering the spread, while the 53.5-point Over/Under is a 58% chance of going Over.

Best Bets for Michigan State vs. Purdue

• Spread: Purdue +2.5 at -105 with DraftKings Sportsbook (54% probability)
• Moneyline: Purdue Win at +125 with DraftKings Sportsbook (3.7% edge)
• Over/Under: Over 53.5 at -106 with FanDuel Sportsbook (58% probability) 🔥

If you see a 🔥, you know it's one of our best bets today across all major pro and college sports.

While Michigan State is more likely to win the game, according to DimersBOT, betting on Purdue moneyline is the best option due to the 3.7% edge identified when comparing our data-led probabilities to the sportsbooks' odds.

Taking advantage of the edges published here at Dimers is crucial to being a profitable bettor in the long run.

MORE: Predictions and best bets for every College Football matchup

Michigan State vs. Purdue Predicted Score

Dimers.com's predicted score for Michigan State vs. Purdue at Ross-Ade Stadium on Saturday is Michigan State 25-25 Purdue.

Dimers has full betting coverage of this week's Michigan State-Purdue game, including pre-game predictions, free picks, live win probabilities, and play-by-play updates.

Remember, DimersBOT updates often, so keep an eye on this page for the latest before Michigan State vs. Purdue on Saturday November 6, 2021.

Michigan State vs. Purdue 2021 CFB Game Info

When does Purdue play Michigan State?

• Date: Saturday November 6, 2021
• Time: 3:30 PM EDT / 12:30 PM PDT
• Venue: Ross-Ade Stadium

Want to join an online sportsbook and start betting on College Football? Check out the best sports betting offers in your state.

Want more College Football previews like this?

To get more College Football betting previews like this one for Michigan State vs. Purdue, all you've gotta do is visit our College Football Betting News page. It's that easy – they're all there!

We use the power of predictive analytics to find edges in the markets so we can write the best CFB betting previews out there. We're able to do this by comparing our accurate and powerful probabilities against the sportsbooks' odds the minute they go live.

So, get ahead of the game and beat the 'books today – it's only a click away.