Michigan State vs. Duke CBB Predictions and Odds - Mar 20, 2022

Duke and Michigan State clash in March Madness action at Bon Secours Wellness Arena on Sunday, starting at 5:15PM EDT.

Dimers' free betting picks for Michigan State vs. Duke, as well as our score prediction and best odds, are detailed in this article.

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Who will win Michigan State vs. Duke?

Using trusted machine learning and data, Dimers.com has simulated Sunday's Michigan State-Duke NCAA Tournament matchup 10,000 times.

Dimers' renowned predictive analytics model, DimersBOT, gives Duke a 72% chance of getting the W against Michigan State.

MORE: Michigan State vs. Duke Simulated 10,000 Times

Point Spread, Moneyline and Over/Under

Duke is the -6.5 favorite against Michigan State, with -110 at PointsBet the best odds currently available.

For the underdog Michigan State (+6.5) to cover the spread, PointsBet also has the best odds currently on offer at -110.

DraftKings Sportsbook currently has the best moneyline odds for Duke at -275, which means you can risk $275 to win $100, for a total payout of $375, if it gets the W.

Meanwhile, BetMGM currently has the best moneyline odds for Michigan State at +230, where you can bet $100 to profit $230, earning a total payout of $330, if it wins.

The Over/Under for total points scored is set at 146.5 with PointsBet, which currently has the best odds for the Over at -110, as well as the best odds for the Under at -110.

As always, make sure you check the sportsbooks you have access to in your state for the best College Basketball odds and lines.

According to DimersBOT, Michigan State (+6.5) is a 51% chance of covering the spread, while the 146.5-point Over/Under is considered an equal 50-50 chance of hitting.

MORE: Best Bets Today for All Major College Sports

Best Bets for Michigan State vs. Duke

• Spread: Michigan State +6.5 at -110 with PointsBet (51% probability)
• Moneyline: Duke at -275 with DraftKings Sportsbook (72% probability)
• Over/Under: Under 146.5 at -110 with PointsBet (50% probability)

Dimers' best bets are based on world-class simulations and betting intelligence to help you make smarter investments with the legal sportsbooks in your state.

Michigan State vs. Duke Score Prediction

Dimers.com's predicted final score for Michigan State vs. Duke at Bon Secours Wellness Arena on Sunday has Duke winning 75-69.

Use our dynamic widget below to view the latest Spread, Over/Under and Moneyline probabilities and odds for the game, and click or tap on See Matchup for more.

Dimers has full betting coverage of Sunday's Michigan State-Duke matchup, including pre-game predictions, computer picks, and live win probabilities.

Remember, DimersBOT updates regularly, so keep checking this article for any changes to our betting insights ahead of Michigan State vs. Duke on Sunday March 20, 2022.

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Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Michigan State vs. Duke 2022 CBB Game Info

When does Duke play Michigan State in College Basketball?

• Date: Sunday March 20, 2022
• Time: 5:15PM EDT / 2:15PM PDT
• Venue: Bon Secours Wellness Arena

Ready to join an online sportsbook and start betting on the NCAA Tournament? Check out the best sports betting offers in your state.

Want more CBB previews like this?

To get more NCAA Basketball betting predictions like you've just read for Michigan State vs. Duke, all you've gotta do is visit Dimers' College Basketball Betting News page. It's that easy – they're all there!

We use the power of predictive analytics to find edges in the markets so we can write the best CBB betting previews out there. We're able to do this by comparing our in-house probabilities against the sportsbooks' odds (aka Vegas odds) the minute they go live.

So, get ahead of the game and beat the 'books today – it's only a click away.

While you're here, Dimers' CBB Futures page is our in-house approach to revealing who will win March Madness 2022, with our data-led probabilities paired with the best odds on the market.