March Madness College Basketball Parlay Picks for Sweet Sixteen Round of 2025 NCAA Tournament on Thursday, March 27

The 2025 March Madness NCAAB Tournament has arrived and we've got our Sweet Sixteen college basketball parlay picks for Thursday, March 27.

After crushing our best bets for the first round of the tournament, we're looking to cash in with three of our bets backed by DimersBOT for the start of the third round.

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Every Dimers Pro edge from Day 2 yielded an 11-4 result, including a near sweep of 3% and up. 🔥

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This is our biggest college basketball season yet - from Dimers Pro to our Dimers Brackets and our brand-new college basketball player prop projections hub, we are armed to the teeth for this year's tournament.

As one of our recurring features this year, we'll be rolling CBB parlays for every round of the tournament. with today's focusing on the Sweet Sixteen games on Thursday, March 27. Today's parlay comes with a special boost from bet365, taking the odds from +378 to +429.

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Every bet and insight featured in our tournament parlays will be sourced directly from our Dimers Pro data, our all-encompassing subscription service featuring our in-house predictive models that run 1000s of simulations on every college basketball game, every day.

Available for less than $1/day, Dimers Pro features the best CBB bets, CBB player props, CBB Futures, parlay picks and CBB betting trends analyzed by our in-house cutting-edge predictive models.

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+429 March Madness Parlay Picks - Thursday, March 27

After simulating each game over 10,000 times, our model has identified the following bets as our best parlay picks for Sweet Sixteen round in the 2025 March Madness tournament.

Note, if you don't have these bets available, consider using the Dimers Pro Parlay Picker to craft a ML/Spreads/Totals parlay for tonight's college basketball games.

Leg 1: BYU vs. Alabama

Alabama enters this matchup as the fastest-paced team in the nation, averaging 90.8 points per game, while BYU has shown a tendency to get drawn into track meets against quicker opponents. The DimersBOT's opening prediction for this game had Alabama winning by exactly six points.

The Cougars rank 71st in adjusted defensive efficiency, a mark that suggests they could struggle to slow down the Crimson Tide’s high-powered attack. Alabama has scored 90 or more points in nine of its last 14 games, only going under against Top 20 teams in adjusted defensive efficiency and if BYU is unable to force a more controlled game, Alabama could dictate the style of play and cover the 4.5-point spread (53% Dimers probability) en route to winning by at least six points. While BYU has the offensive talent to keep up for stretches, Alabama’s ability to push the tempo will hopefully put them in control.

Leg 2: Maryland vs. Florida

Florida’s offensive efficiency will be tested against Maryland’s top-ranked defense since February 1. The Gators prefer to push the tempo, ranking 52nd in adjusted pace, while Maryland will look to slow things down, sitting at 194th in that category.

If Florida can control the pace, they have the tools to pull away late, but if Maryland dictates the tempo, this matchup could remain close throughout. With Florida favored by 6.5 points, their ability to break down the Terrapins' defense will be the key to covering the spread. Additionally, Florida’s edge on the glass could be a deciding factor, as second-chance opportunities may prove crucial against a Maryland squad that thrives in low-possession games.

The Dimers model predicts Florida will cover the 6.5 spread with a 55% probability and a final score of 82-75 in favor of the Gators, winning by at least six.

Leg 3: Duke vs. Arizona

Duke enters this matchup as the No. 1 team in the KenPom rankings, boasting both the top-rated offense and the fourth-best defense. Arizona, ranked 13th overall, has a strong offensive unit but will face one of its toughest tests of the season against Duke’s disciplined defensive scheme.

The Blue Devils have already proven they can handle Arizona, securing a 14-point road win over the Wildcats in November, and their roster has only improved since then. Arizona will need a standout defensive effort to slow Duke’s attack, but with the Blue Devils favored by 9.5 points, oddsmakers expect them to control the game. If Duke maintains its balanced play on both ends, they are well-positioned to advance with another convincing victory, with the Dimers model predicting an 82-72 final score in favor of Duke.

Bet $5 on This Parlay, Get $150 at Bet365 Sportsbook

As Dimers reported today, the Bet365 Bonus Code DIMERS offers new users a $150+ bonus to maximize their betting potential, now extended throughout the tournament. Available in the 13 states where Bet365 is licensed, including newly launched Tennessee and Illinois, this code is the perfect opportunity for sports fans to get in on the action.

To unlock this bonus code and earn $150 in bonus bets on today's college basketball parlay picks, new users simply need to register with Bet365, enter the bonus code DIMERS during sign-up, and place a qualifying wager of $5 or more on today's parlay. Upon doing so, $150 in bonus bets will be credited instantly.

Dimers' 2025 March Madness Betting Resources

• CBB Predictions: Our data-backed previews for every game, every day
• CBB Best Bets: Our Top Picks for every individual matchup
• Best CBB Props: Player edges and projections from our predictive analytics model
• CBB Futures Odds: Who will win the 2025 March Madness Tournament?
• CBB Betting News: The latest promos, storylines and more around the league

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