Louisville vs. Indiana CFB Prediction and Odds - September 16, 2023

Indiana and Louisville lock horns in College Football action at Lucas Oil Stadium on Saturday, starting at 12:00PM ET.

Dimers' top betting picks for Louisville vs. Indiana, plus game predictions and best odds, are detailed in this article.

This Louisville vs. Indiana betting analysis is proudly sponsored by Bet365, which has a Bet $1, Get $365 in Bonus Bets promo for new customers.

Who Will Win: Louisville vs. Indiana

Based on state-of-the-art machine learning and data, Dimers.com has simulated Louisville vs. Indiana 10,000 times.

Dimers' leading predictive analytics model, DimersBOT, currently gives Louisville a 76% chance of winning against Indiana.

More: Louisville vs. Indiana Simulated 10K Times

Louisville vs. Indiana Odds

• Spread: Indiana +10 (-110), Louisville -10 (-110)
• Moneyline: Indiana +285, Louisville -360
• Total: Over/Under 50 (-110/-110)

Indiana is currently the +10 underdog versus Louisville, with -110 at DraftKings Sportsbook the best odds currently available.

For the favored Louisville (-10) to cover the spread, DraftKings Sportsbook also has the best odds currently on offer at -110.

DraftKings Sportsbook currently has the best moneyline odds for Indiana at +285, which means you can bet $100 to profit $285, earning a total payout of $385, if it wins.

Meanwhile, PointsBet currently has the best moneyline odds for Louisville at -360, where you can risk $360 to win $100, for a total payout of $460, if it comes out on top.

The Over/Under for total points scored is set at 50 with PointsBet, which currently has the best odds for the Over at -110, as well as the best odds for the Under at -110.

As always, make sure you check all the sportsbooks available in your state for the best College Football odds and lines.

According to DimersBOT, Indiana (+10) has a 52% chance of covering the spread, while the Over/Under total of 50 points has an equal 50-50 chance of hitting.

More: Free Prop Picks

Best Bets: Louisville vs. Indiana

• Spread: Indiana +10 @ -110 via DraftKings Sportsbook (52% probability)
• Moneyline: Indiana @ +285 via DraftKings Sportsbook
• Total: Under 50 @ -110 via PointsBet (50% probability)

Our best bets are based on world-class modeling and wagering intelligence to bring you the best possible plays 24/7/365.

While Louisville is more likely to win the game, according to DimersBOT, taking Indiana moneyline is the best option due to the edge found when comparing our data-led probabilities to the betting odds currently available.

Taking advantage of the edges published here at Dimers is pivotal to achieving long-term profitability as a sports bettor.

Louisville vs. Indiana Prediction

Dimers.com's predicted final score for Louisville vs. Indiana at Lucas Oil Stadium this Saturday has Louisville winning 29-19.

Click or tap on See Matchup for more information.

Dimers has full coverage of this week's Louisville-Indiana game, including pregame predictions, free picks, and live win probabilities.

Don't forget, DimersBOT updates often, so keep an eye on this article for any changes to our betting insights before Louisville vs. Indiana on Saturday September 16, 2023.

Another great way to make the most of this Louisville vs. Indiana game is by using the latest DraftKings promo, where a bet as small as $5 guarantees you $200 in bonus bets.

Louisville vs. Indiana 2023

Saturday's action between Indiana and Louisville in College Football at Lucas Oil Stadium is scheduled to begin at 12:00PM ET.

• Who: Louisville vs. Indiana
• Date: Saturday September 16, 2023
• Time: 12:00PM ET / 9:00AM PT
• Venue: Lucas Oil Stadium

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Make Smarter Sports Betting Decisions Today

Dimers' picks and predictions are based on 10,000 simulations per game, using reliable and up-to-date data sources and analytical methods.

While these Louisville vs. Indiana picks can help you make informed decisions, it's vital that you only bet what you can afford to lose and manage your bankroll effectively.

To increase your ability to be a responsible gambler, we recommended checking out this full guide to Kentucky sports betting as well as utilizing these .Kentucky sportsbook promos that can get you started off on the right foot.

For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Want More CFB Analysis Like This?

To get more NCAA Football betting previews like you've just read for Louisville vs. Indiana, all you've gotta do is visit Dimers' College Football Betting News page. It's that easy – they're all there!

We use the power of predictive analytics to find value in the markets so we can write the best CFB betting previews available. We're able to do this by comparing our own probabilities against the sportsbooks' odds (aka Vegas odds) as soon as they go live.

So, get ahead of the game and beat the bookies today – check out our College Football picks and predictions.

In addition to our leading CFB predictions, we also feature the best CFB prop bets today, projecting passing yards, touchdowns, and more against the best odds available every day of the CFB season.