Louisville vs. Duke Prediction, Odds, College Basketball Picks [2/28/2024]

Duke will square off with Louisville in college basketball action at Cameron Indoor Stadium on Wednesday, commencing at 7:00PM ET.

Dimers.com's full preview for Wednesday's Louisville vs. Duke matchup includes the latest betting odds, as well as our predictions and picks for the game.

Louisville vs. Duke Prediction: Who Will Win, Cover the Spread

We have used trusted machine learning and data analysis to simulate the result of Wednesday's NCAA basketball matchup between Louisville and Duke 10,000 times, in keeping with our coverage of college basketball picks.

Our independent predictive analytics model currently gives Duke a 94% chance of beating Louisville. Our predicted final score has Duke winning 85-65.

According to our model, Louisville (+20) has a 52% chance of covering the spread, while the 151.5-point Over/Under has a 52% chance of going under.

Louisville vs. Duke Odds

We have researched the best betting odds in America for this game, which are listed here:

Bet Type	Louisville	Duke
Spread	+20 (-105)	-20 (-115)
Moneyline	+1650	-3600
Total	o151.5 (-110)	u151.5 (-105)

• Duke is the -20 favorite against Louisville, with -115 at DraftKings Sportsbook the best odds currently available.
• For the underdog Louisville (+20) to cover the spread, DraftKings also has the best odds currently on offer at -105.
• DraftKings currently has the best moneyline odds for Duke at -3600. That means you can risk $3,600 to win $100 for a total payout of $3,700 if it gets the W.
• BetMGM Sportsbook currently has the best moneyline odds for Louisville at +1650, where you can bet $100 to profit $1,650, earning a total payout of $1,750 if it wins.
• The Over/Under sits at 151.5 with BetMGM, which currently has the best odds for the Over at -110, while FanDuel Sportsbook currently has the best odds for the Under at -105.

All odds are correct at the time of publication and are subject to change.

Louisville vs. Duke Picks

Our predictions, matched with the best odds, reveal the top betting picks for this game, detailed in our college basketball best bets, crafted from expert modeling and analysis:

Bet Type	Our Pick	Best Odds
Spread	Louisville +20	-105
Moneyline	Louisville	+1650
Total	Under 151.5	-105

While Duke is more likely to win the game, taking Louisville moneyline is the best option due to the edge identified when comparing our data-led probabilities to the betting odds currently available.

Louisville vs. Duke Game Information

Wednesday's action between Duke and Louisville in college basketball action at Cameron Indoor Stadium is scheduled to begin at 7:00PM ET.

• Who: Louisville vs. Duke
• Date: Wednesday February 28, 2024
• Time: 7:00PM ET / 4:00PM PT
• Venue: Cameron Indoor Stadium

Our full coverage of Louisville vs. Duke includes pregame predictions, betting picks, and live win probabilities.

Conclusion

This article, enhanced by AI and automation, aims to deliver accurate Louisville vs. Duke insights quickly, with human oversight ensuring high editorial quality. Our predictions are drawn from current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER. Note: Clicking links to our partners may earn us a referral fee.

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