Louisville vs. Duke Prediction: Duke Predicted to Win College Basketball Matchup [3/15/2025]

Duke will face Louisville in college basketball action at Spectrum Center on Saturday, beginning at 8:30PM ET.

Based on the latest simulations, Dimers' advanced college basketball model (see Dimers Pro for full access) predicts Duke as the most likely winner of today's game.

Check the latest March Madness bracket projections and 2025 NCAA Championship probabilities.

"Our team has used the latest data to run 10,000 simulations of Saturday's Louisville-Duke game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various other inputs, we estimate that Duke is more likely to win, while Louisville has a lower chance of victory."

For further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Louisville vs. Duke predictions page.

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Louisville vs. Duke Prediction: Who Will Win, Cover the Spread?

Using powerful machine learning and data, we have simulated the outcome of Saturday's NCAA basketball game between Louisville and Duke 10,000 times as part of our college basketball predictions coverage.

Our famous predictive model gives Duke a 79% chance of beating Louisville. Our predicted final score has Duke winning 78-69.

According to our model, Duke (-6.5) has a 57% chance of covering the spread, while the 148.5-point over/under has an equal 50-50 chance of hitting.

Louisville vs. Duke Odds

We have researched the best College Basketball odds in America for this game, which are listed here:

Bet Type	Louisville	Duke
Spread	+6.5 (-110)	-6.5 (-110)
Moneyline	+220	-250
Total	o148.5 (-105)	u148.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Louisville vs. Duke Picks and Best Bets

Our model's strongest edge in today's Louisville vs. Duke matchup is on the moneyline.

Our expert predictions, matched against the current odds, reveal the best college basketball picks for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Louisville vs. Duke Game-Day Updates and Essential Details

Saturday's college basketball game between Duke and Louisville at Spectrum Center is scheduled to begin at 8:30PM ET.

• Who: Louisville vs. Duke
• Date: Saturday, March 15, 2025
• Time: 8:30PM ET/5:30PM PT
• Venue: Spectrum Center

Dimers.com's comprehensive preview of Saturday's Louisville vs. Duke matchup includes our prediction, picks and the latest betting odds.

Before making any Louisville vs. Duke picks, be sure to check out the latest college basketball predictions and betting advice from Dimers Pro.

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Conclusion

We predict Duke, with a 79% win probability, will likely beat Louisville on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Louisville vs. Duke insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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