Louisville vs. Duke CFB Predictions and Odds - Nov 18, 2021

Duke faces the favored Louisville in College Football Week 12 action at Brooks Field at Wallace Wade Stadium on Thursday, starting at 7:30 PM EST.

Dimers' best betting picks for Louisville vs. Duke, plus our score prediction and best odds, are detailed below.

Who will win Louisville vs. Duke?

Based on advanced machine learning and data, Dimers.com has simulated Thursday's Louisville-Duke NCAA Football matchup 10,000 times.

Dimers' famous predictive analytics model, DimersBOT, gives Louisville an 88% chance of beating Duke.

MORE: Full betting guide for Louisville vs. Duke

Louisville vs. Duke Point Spread, Moneyline and Over/Under

Duke is the +20.5 underdog against Louisville, with -110 at FanDuel Sportsbook the best odds available.

For the favored Louisville (-20.5) to cover the spread, FanDuel Sportsbook also has the best odds on offer at -110.

FanDuel Sportsbook has the best moneyline odds for Duke at +820, which means you can bet $100 to profit $820, earning a total payout of $920, if it wins.

Elsewhere, PointsBet has the best moneyline odds for Louisville at -1250, where you can risk $1250 to win $100, for a total payout of $1350, if it comes out on top.

The Over/Under for total points scored sits at 60.5 with Caesars Sportsbook, which has the best odds for the Over at -110, while FanDuel Sportsbook has the best odds for the Under at -106.

As always, make sure you check the sportsbooks you have access to in your state for the best College Football odds and lines.

According to DimersBOT, Duke (+20.5) is a 53% chance of covering the spread, while the Over/Under total of 60.5 points is a 60% chance of going Over.

Best Bets for Louisville vs. Duke

• Spread: Duke +20.5 at -110 with FanDuel Sportsbook (53% probability)
• Moneyline: Duke Win at +820 with FanDuel Sportsbook (1.0% edge)
• Over/Under: Over 60.5 at -110 with Caesars Sportsbook (60% probability) 🔥

When you see a 🔥, you know it's one of Dimers' best free picks today across any sport.

While Louisville is more likely to win the game, according to DimersBOT, taking Duke moneyline is the best option due to the 1.0% edge identified when comparing our data-led probabilities to the sportsbooks' odds.

Taking advantage of the edges published here at Dimers is pivotal to being a profitable bettor in the long run.

MORE: Best bets today for all major sports

Louisville vs. Duke Score Prediction

Dimers.com's predicted final score for Louisville vs. Duke at Brooks Field at Wallace Wade Stadium this Thursday has Louisville winning 38-18.

Dimers has full betting coverage of this week's Louisville-Duke matchup, including pre-game predictions, computer picks, and live win probabilities.

Remember, DimersBOT updates often, so keep an eye on this article for the latest before Louisville vs. Duke on Thursday November 18, 2021.

Louisville vs. Duke 2021 CFB Game Info

When does Duke play Louisville in College Football?

• Date: Thursday November 18, 2021
• Time: 7:30 PM EST / 4:30 PM PST
• Venue: Brooks Field at Wallace Wade Stadium

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