Louisville vs. Clemson CFB Prediction and Odds - Nov 12, 2022

Clemson and Louisville lock horns in College Football action at Memorial Stadium on Saturday, beginning at 3:30PM ET.

Dimers' free betting picks for Louisville vs. Clemson, plus game predictions and best odds, are detailed in this article.

Who will win Louisville vs. Clemson?

Based on trusted computer power and data, Dimers.com has simulated Louisville vs. Clemson 10,000 times.

Dimers' revolutionary predictive analytics model, DimersBOT, currently gives Clemson a 66% chance of winning against Louisville.

More: Louisville vs. Clemson Simulated 10K Times

Louisville vs. Clemson Odds

• Spread: Clemson -7 (-105), Louisville +7 (-110)
• Moneyline: Clemson -270, Louisville +230
• Total: Over/Under 52.5 (-105/-115)

Point Spread, Moneyline and Over/Under

Clemson is currently the -7 favorite versus Louisville, with -105 at DraftKings Sportsbook the best odds currently available.

For the underdog Louisville (+7) to cover the spread, PointsBet has the best odds currently on offer at -110.

Caesars Sportsbook currently has the best moneyline odds for Clemson at -270, which means you can risk $270 to win $100, for a total payout of $370, if it gets the W.

Elsewhere, DraftKings Sportsbook currently has the best moneyline odds for Louisville at +230, where you can put down $100 to profit $230, earning a total payout of $330, if it wins.

The Over/Under is set at 52.5 with FanDuel Sportsbook, which currently has the best odds for the Over at -105, as well as the best odds for the Under at -115.

As always, make sure you check the sportsbooks you can bet with in your state for the best College Football odds and lines.

According to DimersBOT, Louisville (+7) is a 53% chance of covering the spread, while the 52.5-point Over/Under is a 56% chance of going Under.

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Best Bets for Louisville vs. Clemson

• Spread: Louisville +7 @ -110 via PointsBet (53% probability)
• Moneyline: Louisville @ +230 via DraftKings Sportsbook (3.2% edge)
• Total: Under 52.5 @ -115 via FanDuel Sportsbook (56% probability)

Dimers' best bets are based on complex simulations and wagering expertise to help you make more informed investments with your state's legal sportsbooks.

While Clemson is more likely to win the game, according to DimersBOT, taking Louisville moneyline is the best option because of the 3.2% edge identified when comparing our data-led probabilities to the sportsbooks' odds currently on offer.

Taking advantage of the edges published here at Dimers is pivotal to achieving long-term profitability.

Louisville vs. Clemson Prediction

Dimers.com's predicted final score for Louisville vs. Clemson at Memorial Stadium this Saturday has Clemson winning 28-22.

Click or tap on See Matchup to reveal more.

Dimers has full coverage of this week's Louisville-Clemson matchup, including pregame predictions, free picks, and live scores.

Remember, DimersBOT updates frequently, so keep checking this article for any changes to our betting insights ahead of Louisville vs. Clemson on Saturday November 12, 2022.

Louisville vs. Clemson 2022 CFB Game Info

Saturday's game between Clemson and Louisville in College Football at Memorial Stadium is scheduled to commence at 3:30PM ET.

• Who: Louisville vs. Clemson
• Date: Saturday November 12, 2022
• Time: 3:30PM ET / 12:30PM PT
• Venue: Memorial Stadium

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Want more College Football analysis like this?

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