Los Angeles Rams vs. San Francisco 49ers Prediction, Odds, NFL Picks - Week 18 [2024]

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Written by Ryan Leaver
Los Angeles Rams vs. San Francisco 49ers Prediction, Odds, NFL Picks - Week 18 [2024]

The San Francisco 49ers and Los Angeles Rams will lock horns in Week 18 of the NFL season at Levi's Stadium on Sunday, with kickoff at 4:25PM ET.

Dimers.com's full betting preview for this week's Rams vs. 49ers matchup includes the latest betting odds, as well as our predictions and picks for the game.

Rams vs. 49ers Prediction: Who Will Win, Cover the Spread

We have used innovative machine learning and statistical analysis to simulate the result of Sunday's NFL matchup between the Rams and 49ers 10,000 times, in keeping with our coverage of NFL predictions.

Our leading predictive analytics model gives the 49ers a 72% chance of beating the Rams in Week 18 of the NFL season, and our predicted final score has the 49ers winning 24-18.

According to our model, the bookmakers have got it right, and both the Rams and 49ers have a 50% chance of covering the spread, while the Over/Under total of 40.5 points also has a 55% chance of going over.

This LA Rams vs. San Francisco betting preview is brought to you by Bet365, which has an outstanding Bet $5, Get $150 in Bonus Bets promo for new users.

Rams vs. 49ers Odds

We have sourced the best betting odds in America for this game, which are listed here:

Bet Type Rams 49ers
Spread +5.5 (-105) -5.5 (-110)
Moneyline +225 -245
Total o40.5 (-102) u40.5 (-120)
  • The 49ers are listed as -5.5 favorites versus the Rams, with -110 at BetMGM Sportsbook the best odds currently available.
  • For the underdog Rams (+5.5) to cover the spread, FanDuel Sportsbook has the best odds currently on offer at -105.
  • DraftKings Sportsbook currently has the best moneyline odds for the 49ers at -245. That means you can risk $245 to win $100 for a total payout of $345 if they get the W.
  • Elsewhere, FanDuel currently has the best moneyline odds for the Rams at +225, where you can bet $100 to profit $225, earning a total payout of $325 if they win.
  • The Over/Under is set at 40.5 with FanDuel, which currently has the best odds for the Over at -102, as well as the best odds for the Under at -120.

All odds are correct at the time of publication and are subject to change.

As always, check out the sportsbooks you can bet with in your state for the best NFL odds and lines.

Rams vs. 49ers Picks

By comparing our predictions to the odds listed above, we have determined the best betting picks to place on this game:

Bet Type Our Pick Best Odds
Spread Rams +5.5 -105
Moneyline 49ers -245
Total Over 40.5 -102

 

If you see a 🔥, that means it's one of our best bets of the day across all major pro and college sports.

Our best NFL bets are based on detailed simulations and wagering intelligence to bring you the best possible plays every week of the season.

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Rams vs. 49ers TD Scorers

Who will score the first touchdown in Rams vs. 49ers?

According to our model, San Francisco's Jordan Mason is most likely to score the first TD in Rams vs. 49ers.

Our projections give Mason a 10.5% chance of scoring the first TD at Levi's Stadium, while the 49ers RB is a 39.6% chance of reaching the end zone at any point in the game.

First Touchdown Scorer Predictions

Los Angeles Rams

Player First TD Probability
Ronnie Rivers 8.3%
Demarcus Robinson 6.4%
Royce Freeman 6.2%
Puka Nacua 5.8%
Tutu Atwell 5.2%

San Francisco 49ers

Player First TD Probability
Jordan Mason 10.5%
Elijah Mitchell 9.8%
Brandon Aiyuk 5.7%
Ronnie Bell 5.4%
Deebo Samuel 5.2%

Anytime Touchdown Scorer Predictions

Los Angeles Rams

Player Anytime TD Probability
Ronnie Rivers 34.4%
Demarcus Robinson 27.2%
Royce Freeman 25.7%
Puka Nacua 24.2%
Tutu Atwell 21.8%

San Francisco 49ers

Player Anytime TD Probability
Jordan Mason 39.6%
Elijah Mitchell 38.9%
Brandon Aiyuk 23.3%
Ronnie Bell 23.0%
Deebo Samuel 21.6%

Rams vs 49ers Player Props

Here, you will find detailed projections for all of the key offensive players from the Rams and 49ers, including passing, rushing and receiving yards.

Rams vs. 49ers Quarterbacks

Of the starting quarterbacks, the Rams' Carson Wentz is projected for 197 passing yards. The 49ers' Sam Darnold is expected to throw for just 185 yards.

Player Proj. Pass Yards
Carson Wentz (LA) 197 yds
Sam Darnold (SF) 185 yds

Rams Rushing

Player Proj. Rush Yards
Ronnie Rivers 44 yds
Royce Freeman 31 yds
Zach Evans 18 yds

49ers Rushing

Player Proj. Rush Yards
Jordan Mason 49 yds
Elijah Mitchell 31 yds
Sam Darnold 22 yds

Rams Receiving

Player Proj. Rec. Yards
Puka Nacua 40 yds
Demarcus Robinson 39 yds
Tutu Atwell 34 yds
Ben Skowronek 24 yds
Davis Allen 20 yds

49ers Receiving

Player Proj. Rec. Yards
Ronnie Bell 37 yds
Chris Conley 33 yds
Deebo Samuel 31 yds
Brandon Aiyuk 25 yds
George Kittle 19 yds

Remember, our model updates frequently, so check this page for any changes to our betting analysis before the Rams vs. 49ers on Sunday January 7, 2024.

Rams vs. 49ers Game Information

The NFL Week 18 action between the 49ers and Rams at Levi's Stadium is scheduled to start at 4:25PM ET.

 

Our full betting coverage of Rams vs. 49ers includes pregame predictions, betting picks, and live win probabilities.

How to Bet on Rams vs. 49ers

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These fees help us keep Dimers free for sports fans like you. So, if you like what you see, support us by joining one of our featured sports betting partners below, including DraftKings Sportsbook, where you get $200 in bonus bets for signing up and bettting $5 on LA Rams vs. San Francisco.

Conclusion

This preview article has been partially generated using automated processes and AI technology. Our goal is to provide timely and accurate updates on Rams vs. 49ers Week 14 contest, and automation assists in data collection, analysis, and formatting. Human editing and quality control are performed to ensure the content meets our editorial guidelines.

Dimers' picks are based on 10,000 simulations per game, using reliable and up-to-date data sources and analytical methods. While these Rams vs. 49ers picks can help you make informed decisions, it's crucial that you gamble responsibly and manage your finances effectively.

For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

When you click or tap on a link on Dimers that goes to a third-party website that we have a commercial relationship with (such as a sportsbook), we may get a referral fee at no additional cost to you.

More on NFL

Stay informed with the latest NFL news and our data-led NFL picks and parlays all season long. Plus, our Super Bowl odds give you the latest projections and the best available odds on the Super Bowl, AFC, NFC, and each division.

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Written by
Ryan Leaver
Senior Sports and Sports Betting Editor

Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.

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