Rams vs. 49ers Prediction: San Francisco Predicted to Win TNF Week 15 [2024]

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Written by Jason Bevilacqua

Our expert prediction for Thursday's Los Angeles Rams vs San Francisco 49ers matchup.

Los Angeles Rams-San Francisco 49ers Predictions and Game Preview.
Levi's Stadium sets the stage for the NFL matchup between the Los Angeles Rams and San Francisco 49ers this Thursday.

The San Francisco 49ers and Los Angeles Rams will meet in Week 15 of the NFL season at Levi's Stadium on Thursday, with kickoff at 8:15PM ET.

Based on updated simulations, Dimers' proven NFL model (see Dimers Pro for full access) predicts the 49ers as the most likely winner of today's game.

"Using the latest data, our experts simulated Thursday's LA Rams-San Francisco game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Taking into account recent updates and various additional inputs, we forecast the 49ers with a win probability of 59% and the Rams with 41%."

This updated Rams vs. 49ers betting preview builds on my early Rams vs. 49ers prediction that I released at the start of the week.

For further insights into today’s game, including the predicted score, best bets and player prop picks, visit our interactive Rams vs. 49ers predictions page.

READER EXCLUSIVE: Use code 20FOOTBALL at checkout now to get 20% off your first month of Dimers Pro! Hurry, this offer won't last long.

Rams vs. 49ers Game-Day Updates and Essential Details

The NFL Week 15 matchup between the 49ers and Rams at Levi's Stadium is scheduled to begin at 8:15PM ET.

Dimers.com's comprehensive preview of Thursday's Rams vs. 49ers matchup includes our prediction, picks and the latest betting odds.

Before making any LA Rams vs. San Francisco picks, be sure to check out the latest NFL predictions and betting advice from Dimers Pro.

Rams vs. 49ers Predictions

Using powerful machine learning and statistical analysis, we have simulated the result of Thursday's NFL matchup between the Rams and 49ers 10,000 times as part of our NFL predictions coverage.

Our famous predictive model gives the 49ers a 59% chance of defeating the Rams in Week 15 of the NFL season. Our predicted final score has the 49ers winning 25-22.

According to our model, the 49ers (-2.5) have a 56% chance of covering the spread, while the 49-point over/under has a 51% chance of staying under.

 

In addition to our Rams vs. 49ers predictions, we've also prepared the following for this week's action:

Rams vs. 49ers Odds

We have sourced the best betting odds in America for this game, which are listed here:

Bet Type Rams 49ers
Spread +2.5 (-105) -2.5 (-125)
Moneyline +134 -150
Total o49 (-110) u49 (-110)

All odds are correct at the time of publication and are subject to change.

Rams vs. 49ers Picks

Our model's strongest edge in today's Rams vs. 49ers matchup is on the over/under.

Our expert predictions, matched against the latest odds, reveal the best NFL picks for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

Rams vs. 49ers TD Scorers

Who will score an anytime touchdown in Rams vs. 49ers?

According to our model, Los Angeles' Kyren Williams is most likely to score the first touchdown in Rams vs. 49ers.

Our projections give Williams a 12.3% chance of getting in for six first at Levi's Stadium, while the Rams RB is a 52.9% chance of reaching the end zone at any point in the game.

First Touchdown Scorer Predictions

Los Angeles Rams

Player First TD Probability
Kyren Williams 12.3%
Puka Nacua 9.3%
Cooper Kupp 8.2%

San Francisco 49ers

Player First TD Probability
Isaac Guerendo 10.1%
George Kittle 10.0%
Deebo Samuel 8.8%

Anytime Touchdown Scorer Predictions

Los Angeles Rams

Player Anytime TD Probability
Kyren Williams 52.9%
Puka Nacua 42.0%
Cooper Kupp 38.2%

San Francisco 49ers

Player Anytime TD Probability
Isaac Guerendo 45.1%
George Kittle 43.5%
Deebo Samuel 39.1%

Rams vs 49ers Player Props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Rams and 49ers. For detailed projections, join Dimers Pro.

Already a Dimers Pro member? Head to our Rams-49ers page now to access every player prop projection.

Rams vs. 49ers Quarterbacks

Of the starting quarterbacks, the Rams' Matthew Stafford is projected to throw for fewer yards than the 49ers' Brock Purdy.

Rams Rushing

Kyren Williams, Blake Corum and Matthew Stafford are projected to be the leading rushers for the Rams.

Player Position
Kyren Williams RB
Blake Corum RB
Matthew Stafford QB

49ers Rushing

Isaac Guerendo, Patrick Taylor and Brock Purdy are expected to lead the 49ers in rushing yards.

Player Position
Isaac Guerendo RB
Patrick Taylor RB
Brock Purdy QB

Rams Receiving

Puka Nacua, Cooper Kupp, Demarcus Robinson, Tutu Atwell and Colby Parkinson are projected to top the receiving yards for the Rams.

Player Position
Puka Nacua WR
Cooper Kupp WR
Demarcus Robinson WR
Tutu Atwell WR
Colby Parkinson TE

49ers Receiving

George Kittle, Jauan Jennings, Deebo Samuel, Ricky Pearsall and Isaac Guerendo are projected to lead the 49ers in receiving yards.

Player Position
George Kittle TE
Jauan Jennings WR
Deebo Samuel WR
Ricky Pearsall WR
Isaac Guerendo RB

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Conclusion

We predict the 49ers, with a 59% win probability, will likely beat the Rams in Week 15 of the NFL season.

AI and automation have enhanced this article to quickly deliver accurate Rams vs. 49ers insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on NFL

Keep up with the latest NFL news, NFL best bets and NFL parlay picks throughout the season. Plus, our Super Bowl odds offer the most up-to-date projections for the Super Bowl, AFC, NFC and each division.

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Written by
Jason Bevilacqua
Head of Content and Communities

Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.

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