Dodgers vs. Cubs Prediction: Dodgers Predicted to Win Tuesday's MLB Matchup [4/22/2025]

The Chicago Cubs and Los Angeles Dodgers will lock horns in MLB action at Wrigley Field on Tuesday, starting at 7:40PM ET.

Shota Imanaga (2-1, 2.22 ERA) will start for the Cubs, pitting him against Dustin May (1-1, 1.06 ERA) for the Dodgers.

Based on updated simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) predicts the Dodgers as the most likely winner of today's game.

"Our team has analyzed the latest data and conducted 10,000 simulations for Tuesday's LA Dodgers-CHI Cubs game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various factors, our prediction shows the Dodgers with a win probability of 51%, compared to 49% for the Cubs."

For a closer look at Tuesday's matchup, including best bets and picks, visit our interactive Dodgers vs. Cubs predictions page.

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Cubs vs. Dodgers Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data, we have simulated the outcome of Tuesday's MLB matchup between the Dodgers and Cubs 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Dodgers a 51% chance of defeating the Cubs.

According to our model, the Cubs (+1.5) have a 60% chance of covering the run line, while the 9-run over/under has a 58% chance of staying under.

Pre-Game Probabilities

Last Updated: 11:31PM, Apr 22

Moneyline

Over / Under

Run Line

Dodgers

Win %

51%

49%

-115

+100

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Cubs

Dodgers LAD

-115

Win %

51%

49%

See Matchup

Cubs CHC

+100

Dustin May 1-1, 1.06 ERA

Shota Imanaga 2-1, 2.22 ERA

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Dodgers vs. Cubs Odds [4/22/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Dodgers vs. Cubs Picks and Best Bets

Our model's biggest edge in today's Dodgers vs. Cubs matchup is on the run line.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Best Bets

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Dodgers vs. Cubs Game-Day Updates and Essential Details

Tuesday's MLB action between the Cubs and Dodgers at Wrigley Field is scheduled to begin at 7:40PM ET.

• Who: Los Angeles Dodgers vs. Chicago Cubs
• Date: Tuesday, April 22, 2025
• Time: 7:40PM ET/4:40PM PT
• Venue: Wrigley Field

Dimers.com's comprehensive preview of Tuesday's Dodgers vs. Cubs matchup includes our prediction, picks and the latest betting odds.

Before making any LA Dodgers vs. CHI Cubs picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Dodgers, with a 51% win probability, will likely beat the Cubs on Tuesday.

AI and automation have enhanced this article to quickly deliver accurate Dodgers vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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