Kentucky vs. Louisville CFB Predictions and Odds - Nov 27, 2021

Louisville and Kentucky are scheduled to meet in Week 13 of the College Football season at Cardinal Stadium on Saturday, with kickoff at 7:30 PM EST.

Dimers' top betting picks for Kentucky vs. Louisville, as well as game predictions and best odds, are detailed in this article.

Who will win Kentucky vs. Louisville?

Based on high-tech computer power and data, Dimers.com has simulated Saturday's Kentucky-Louisville NCAA Football game 10,000 times.

Dimers' independent predictive analytics model, DimersBOT, gives Louisville a 59% chance of defeating Kentucky.

MORE: Kentucky vs. Louisville Simulated 10,000 Times

Kentucky vs. Louisville Point Spread, Moneyline and Over/Under

Louisville is the -3 favorite against Kentucky, with -105 at PointsBet the best odds available.

For the underdog Kentucky (+3) to cover the spread, Caesars Sportsbook has the best odds on offer at -115.

DraftKings Sportsbook has the best moneyline odds for Louisville at -140. That means you can risk $140 to win $100, for a total payout of $240, if it gets the W.

Elsewhere, PointsBet has the best moneyline odds for Kentucky at +125, where you can bet $100 to profit $125, earning a total payout of $225, if it wins.

The Over/Under for total points scored sits at 57.5 with Caesars Sportsbook, which has the best odds for the Over at -110, as well as the best odds for the Under at -110.

As always, make sure you check all the online sportsbooks available in your state for the best College Football odds and lines.

According to DimersBOT, Louisville (-3) is a 53% chance of covering the spread, while the Over/Under total of 57.5 points is a 51% chance of going Over.

MORE: Predictions for Every CFB Game

Best Bets for Kentucky vs. Louisville

• Spread: Louisville -3 at -105 with PointsBet (53% probability)
• Moneyline: Louisville Win at -140 with DraftKings Sportsbook (59% probability)
• Over/Under: Over 57.5 at -110 with Caesars Sportsbook (51% probability)

Kentucky vs. Louisville Score Prediction

Dimers.com's predicted final score for Kentucky vs. Louisville at Cardinal Stadium this Saturday has Louisville winning 30-26.

Use our interactive widget below to view the current Spread, Over/Under and Moneyline probabilities and odds for the game, and click or tap on See Matchup to reveal more.

Dimers has full coverage of this week's Kentucky-Louisville matchup, including pre-game predictions, computer picks, and live scores.

Don't forget, DimersBOT updates often, so check this page for the latest betting insights ahead of Kentucky vs. Louisville on Saturday November 27, 2021.

Kentucky vs. Louisville 2021 CFB Game Info

When does Louisville play Kentucky in College Football?

• Date: Saturday November 27, 2021
• Time: 7:30 PM EST / 4:30 PM PST
• Venue: Cardinal Stadium

Want to join an online sportsbook and start betting on College Football? Check out the best sports betting promos in your state.

Want more College Football predictions like this?

To get more NCAA Football betting previews like this one for Kentucky vs. Louisville, all you've gotta do is visit our College Football Betting News page. It's that easy – they're all there!

We use the power of predictive analytics to find edges in the markets so we can publish the best CFB betting previews out there. We're able to do this by comparing our own probabilities against the sportsbooks' odds (aka Vegas odds) as soon as they go live.

So, get ahead of the game and beat the 'books today – it's only a click away.