Kei Nishikori vs. Denis Shapovalov Prediction, Odds, Picks for ATP Madrid Open 2025

Kei Nishikori will square off with Denis Shapovalov in the round of 64 at the ATP Madrid event on Saturday.

Based on the latest simulation results, Dimers' advanced tennis model (see Dimers Pro for full access) predicts Denis Shapovalov as the most likely winner of the match.

"We have used the latest data to run 10,000 simulations of Saturday's Nishikori-Shapovalov match," said Dimers data analyst Greg Butyn.

"By incorporating recent updates and various other inputs, we estimate that Denis Shapovalov is more likely to win, while Kei Nishikori has a lower chance of victory."

For further insights into Saturday's match, including best bets and picks, visit our interactive Nishikori vs. Shapovalov predictions page.

Get 20% off Dimers Pro With Code 20TENNIS

Get Dimers Pro

Nishikori vs. Shapovalov Prediction: Who Will Win and Advance to the Round of 32?

Using powerful machine learning and data, we have simulated the result of Saturday's Nishikori-Shapovalov men's singles match 10,000 times as part of our tennis predictions coverage.

Our leading predictive model gives Shapovalov a 52% chance of defeating Nishikori at the ATP Madrid Open tournament.

Additionally, Shapovalov has a 52% chance of winning the first set, according to our model.

Pre-Match Probabilities

Last Updated: 4:06PM, Apr 26

Moneyline

1st Set

KeiNishikori

Win %

48%

52%

+110

-139

Get the best bets with Dimers Pro

See Matchup

Get Dimers Pro

DenisShapovalov

KeiNishikori

+110

Win %

48%

52%

See Matchup

DenisShapovalov

-139

Get the best bets with Dimers Pro

Get Dimers Pro

For more insights into the growing popularity of betting on the sport, check out our comprehensive analysis of tennis' rise in the U.S. sports betting market.

Kei Nishikori vs. Denis Shapovalov Odds

We have sourced the most up-to-date betting odds in America for this match, which are listed here:

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Nishikori vs. Shapovalov Picks and Best Bets

Our model's biggest edge in today's Nishikori vs. Shapovalov match is on the first set.

Our expert predictions, matched against the current odds, reveal the best tennis picks and tennis best bets for every tournament throughout the year.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Unlock Every ATP Madrid Open Pick

Get Dimers Pro

Nishikori vs. Shapovalov Updates and Essential Details

The ATP Madrid Open match between Kei Nishikori and Denis Shapovalov is scheduled to begin on Saturday at 5:00AM ET.

• Who: Kei Nishikori vs. Denis Shapovalov
• Date: Saturday, April 26, 2025
• Approx. Time: 5:00AM ET/2:00AM PT
• Tournament: ATP Madrid, Spain Men's Singles 2025
• Round: Round of 64

All dates and times in this article are United States Eastern Time unless otherwise noted.

Dimers.com's full preview of Saturday's Nishikori vs. Shapovalov match includes our prediction, picks and the latest betting odds.

Before making any Kei Nishikori vs. Denis Shapovalov picks, be sure to check out the latest tennis predictions and betting advice from Dimers Pro.

Key Tennis Betting Guides and Insights

• Learn how to bet on tennis and understand how tennis odds work
• Explore where sports odds come from and how they’re applied to tennis matches
• Stay informed with guides on where online sports betting is currently legal and which states could legalize next
• Improve your chances with proven sports betting strategies that apply to tennis and more

Conclusion

We predict Denis Shapovalov, with a 52% win probability, will likely beat Kei Nishikori at the ATP Madrid Open tournament.

AI and automation have enhanced this article to quickly deliver accurate Nishikori vs. Shapovalov insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on Tennis

Keep up with the latest tennis news and parlay picks throughout the year. Plus, Dimers' ATP and WTA world rankings showcase our in-house approach to accurately ranking every men's and women's player in the world.