Karen Khachanov vs. Reilly Opelka Prediction, Odds, Picks for ATP Madrid Open 2025

Karen Khachanov and Reilly Opelka will lock horns in the round of 64 of the ATP Madrid Open event on Saturday.

Based on updated simulation results, Dimers' advanced tennis model (see Dimers Pro for full access) predicts Karen Khachanov as the most likely winner of the match.

"We have used the latest data to run 10,000 simulations of Saturday's Khachanov-Opelka match," said Dimers data analyst Greg Butyn.

"By incorporating recent updates and various other inputs, we estimate that Karen Khachanov is more likely to win, while Reilly Opelka has a lower chance of victory."

For expanded analysis of Saturday's match, including best bets and picks, visit our interactive Khachanov vs. Opelka predictions page.

Khachanov vs. Opelka Prediction: Who Will Win and Advance to the Round of 32?

Using trusted machine learning and data, we have simulated the outcome of Saturday's Khachanov-Opelka men's singles match 10,000 times as part of our tennis predictions coverage.

Our famous predictive model currently gives Khachanov a 70% chance of defeating Opelka at the ATP Madrid Open tournament.

Additionally, Khachanov has a 66% chance of winning the first set, according to our model.

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Karen Khachanov vs. Reilly Opelka Odds

We have sourced the most up-to-date betting odds in America for this match, which are listed here:

Bet Type	Khachanov	Opelka
Moneyline	-333	+250
First Set	-250	+200

All odds are correct at the time of publication and are subject to change.

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Khachanov vs. Opelka Picks and Best Bets

Our model's biggest edge in today's Khachanov vs. Opelka match is on the moneyline.

Our expert predictions, matched against the latest odds, reveal the best tennis picks and tennis best bets for every match throughout the year.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Khachanov vs. Opelka Updates and Essential Details

The ATP Madrid Open match between Karen Khachanov and Reilly Opelka is scheduled to begin on Saturday at 2:30PM ET.

• Who: Karen Khachanov vs. Reilly Opelka
• Date: Saturday, April 26, 2025
• Approx. Time: 2:30PM ET/11:30AM PT
• Tournament: ATP Madrid, Spain Men's Singles 2025
• Round: Round of 64

All dates and times in this article are United States Eastern Time unless otherwise noted.

Dimers.com's full preview of Saturday's Khachanov vs. Opelka match includes our prediction, picks and the latest betting odds.

Before making any Karen Khachanov vs. Reilly Opelka picks, be sure to check out the latest tennis predictions and betting advice from Dimers Pro.

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Conclusion

We predict Karen Khachanov, with a 70% win probability, will likely beat Reilly Opelka at the ATP Madrid Open tournament.

AI and automation have enhanced this article to quickly deliver accurate Khachanov vs. Opelka insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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