Karen Khachanov vs. Reilly Opelka Prediction, Odds, Picks for ATP Madrid Open 2025

Karen Khachanov and Reilly Opelka will lock horns in the round of 64 of the ATP Madrid Open event on Saturday.

Based on updated simulation results, Dimers' advanced tennis model (see Dimers Pro for full access) predicts Karen Khachanov as the most likely winner of the match.

"We have used the latest data to run 10,000 simulations of Saturday's Khachanov-Opelka match," said Dimers data analyst Greg Butyn.

"By incorporating recent updates and various other inputs, we estimate that Karen Khachanov is more likely to win, while Reilly Opelka has a lower chance of victory."

For expanded analysis of Saturday's match, including best bets and picks, visit our interactive Khachanov vs. Opelka predictions page.

Get 20% off Dimers Pro With Code 20TENNIS

Get Dimers Pro

Khachanov vs. Opelka Prediction: Who Will Win and Advance to the Round of 32?

Using trusted machine learning and data, we have simulated the outcome of Saturday's Khachanov-Opelka men's singles match 10,000 times as part of our tennis predictions coverage.

Our famous predictive model currently gives Khachanov a 70% chance of defeating Opelka at the ATP Madrid Open tournament.

Additionally, Khachanov has a 66% chance of winning the first set, according to our model.

Pre-Match Probabilities

Last Updated: 11:04PM, Apr 26

Moneyline

1st Set

KarenKhachanov

Win %

70%

30%

-333

+250

Get the best bets with Dimers Pro

See Matchup

Get Dimers Pro

ReillyOpelka

KarenKhachanov

-333

Win %

70%

30%

See Matchup

ReillyOpelka

+250

Get the best bets with Dimers Pro

Get Dimers Pro

For more insights into the growing popularity of betting on the sport, check out our comprehensive analysis of tennis' rise in the U.S. sports betting market.

Karen Khachanov vs. Reilly Opelka Odds

We have sourced the most up-to-date betting odds in America for this match, which are listed here:

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Khachanov vs. Opelka Picks and Best Bets

Our model's biggest edge in today's Khachanov vs. Opelka match is on the moneyline.

Our expert predictions, matched against the latest odds, reveal the best tennis picks and tennis best bets for every match throughout the year.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Unlock Every ATP Madrid Open Pick

Get Dimers Pro

Khachanov vs. Opelka Updates and Essential Details

The ATP Madrid Open match between Karen Khachanov and Reilly Opelka is scheduled to begin on Saturday at 2:30PM ET.

• Who: Karen Khachanov vs. Reilly Opelka
• Date: Saturday, April 26, 2025
• Approx. Time: 2:30PM ET/11:30AM PT
• Tournament: ATP Madrid, Spain Men's Singles 2025
• Round: Round of 64

All dates and times in this article are United States Eastern Time unless otherwise noted.

Dimers.com's full preview of Saturday's Khachanov vs. Opelka match includes our prediction, picks and the latest betting odds.

Before making any Karen Khachanov vs. Reilly Opelka picks, be sure to check out the latest tennis predictions and betting advice from Dimers Pro.

Key Tennis Betting Guides and Insights

• Learn how to bet on tennis and understand how tennis odds work
• Explore where sports odds come from and how they’re applied to tennis matches
• Stay informed with guides on where online sports betting is currently legal and which states could legalize next
• Improve your chances with proven sports betting strategies that apply to tennis and more

Sports Betting Deals Available for Saturday

To make the most of Saturday's exciting day of sports, headlined by a huge day of NBA and NHL playoffs action, check out details on the latest Bet365 bonus code "DIMERS" that grants you the choice of two excellent signup promotions.

Plus, find out all the details on the BetMGM bonus code "DIMERS150" which is now available in New Jersey, Pennsylvania, Michigan, Colorado, and West Virginia. Don't miss out!

Conclusion

We predict Karen Khachanov, with a 70% win probability, will likely beat Reilly Opelka at the ATP Madrid Open tournament.

AI and automation have enhanced this article to quickly deliver accurate Khachanov vs. Opelka insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on Tennis

Stay informed with the latest tennis betting news and parlay picks throughout the year. Plus, Dimers' ATP and WTA world rankings showcase our in-house approach to accurately ranking every men's and women's player in the world.