Royals vs. Guardians Prediction: Cleveland Predicted to Win Saturday's MLB Matchup [4/12/2025]

The Cleveland Guardians and Kansas City Royals will lock horns in MLB action at Progressive Field on Saturday, starting at 6:10PM ET.

Luis L. Ortiz (0-2, 8.44 ERA) will be the starting pitcher for the Guardians, pitting him against Michael Lorenzen (1-1, 3.18 ERA) for the Royals.

Based on the latest simulation results, Dimers' advanced MLB model (see Dimers Pro for full access) projects the Guardians as the most likely winner of today's game.

"Our team has used the latest data to run 10,000 simulations of Saturday's Kansas City-Cleveland game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various other inputs, we estimate that the Guardians are more likely to win, while the Royals have a lower chance of victory."

For further insights into Saturday's matchup, including best bets and picks, visit our interactive Royals vs. Guardians predictions page.

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Royals vs. Royals Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data, we have simulated the result of Saturday's MLB matchup between the Royals and Guardians 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Guardians a 53% chance of defeating the Royals.

According to our model, the Royals (+1.5) have a 65% chance of covering the run line, while the 8-run over/under has an equal 50-50 chance of hitting.

Pre-Game Probabilities

Last Updated: 10:27PM, Apr 12

Moneyline

Over / Under

Run Line

Royals

Win %

47%

53%

+135

-135

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Guardians

Royals KC

+135

Win %

47%

53%

See Matchup

Guardians CLE

-135

Michael Lorenzen 1-1, 3.18 ERA

Luis Ortiz 0-2, 8.44 ERA

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Royals vs. Guardians Odds [4/12/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Royals vs. Guardians Picks and Best Bets

Our model's biggest edge in today's Royals vs. Guardians matchup is on the moneyline.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

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Calling Our Shot produces daily MLB betting content, including the free picks featured below.

Royals vs. Guardians Game-Day Updates and Essential Details

Saturday's MLB action between the Guardians and Royals at Progressive Field is scheduled to begin at 6:10PM ET.

• Who: Kansas City Royals vs. Cleveland Guardians
• Date: Saturday, April 12, 2025
• Time: 6:10PM ET/3:10PM PT
• Venue: Progressive Field

Dimers.com's comprehensive preview of Saturday's Royals vs. Guardians matchup includes our prediction, picks and the latest betting odds.

Before making any Kansas City vs. Cleveland picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Guardians, with a 53% win probability, will likely beat the Royals on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Royals vs. Guardians insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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