James Madison vs. Louisville CFB Prediction and Odds - Nov 5, 2022

Last updated: Dec 21, 2023, 4:13PM | Published: Oct 31, 2022, 4:01AM

Louisville and James Madison lock horns in College Football action at Cardinal Stadium on Saturday, starting at 7:30PM ET.

Dimers' free betting picks for James Madison vs. Louisville, as well as our score prediction and betting odds, are featured below.

Who will win James Madison vs. Louisville?

Using high-tech machine learning and data, Dimers.com has simulated James Madison vs. Louisville 10,000 times.

Dimers' independent predictive analytics model, DimersBOT, gives Louisville a 61% chance of winning against James Madison.

More: James Madison vs. Louisville Simulated 10K Times

James Madison vs. Louisville Game Odds

Spread: Louisville -6.5 (-110), James Madison +6.5 (-110)
Moneyline: Louisville -255, James Madison +222
Total: Over/Under 52.5 (-110/-105)

Point Spread, Moneyline and Over/Under

Louisville is currently the -6.5 favorite versus James Madison, with -110 at Caesars Sportsbook the best odds currently available.

For the underdog James Madison (+6.5) to cover the spread, Caesars Sportsbook also has the best odds currently on offer at -110.

FanDuel Sportsbook currently has the best moneyline odds for Louisville at -255, which means you can risk $255 to win $100, for a total payout of $355, if it gets the W.

On the other hand, Caesars Sportsbook currently has the best moneyline odds for James Madison at +222, where you can bet $100 to profit $222, earning a total payout of $322, if it wins.

The Over/Under for total points scored sits at 52.5 with Caesars Sportsbook, which currently has the best odds for the Over at -110, while PointsBet currently has the best odds for the Under at -105.

As always, make sure you check the sportsbooks you can bet with in your state for the best College Football odds and lines.

According to DimersBOT, James Madison (+6.5) is a 55% chance of covering the spread, while the Over/Under total of 52.5 points is a 54% chance of going Over.

More: Best Prop Bets to Make Today

Best Bets for James Madison vs. Louisville

Spread: James Madison +6.5 @ -110 via Caesars Sportsbook (55% probability)
Moneyline: James Madison @ +222 via Caesars Sportsbook (8.3% edge) 🔥
Total: Over 52.5 @ -110 via Caesars Sportsbook (54% probability)

Every time you see a 🔥, you know it's one of our best free picks today across all sports.

Dimers' best bets are based on world-class simulations and gambling expertise to help you make more informed decisions with your state's legal sportsbooks.

While Louisville is more likely to win the game, according to DimersBOT, taking James Madison moneyline is the best option because of the 8.3% edge found when comparing our data-led probabilities to the betting odds currently available.

Taking advantage of the edges seen here at Dimers is one of the keys to achieving long-term profitability.

James Madison vs. Louisville Prediction

Dimers.com's predicted final score for James Madison vs. Louisville at Cardinal Stadium this Saturday has Louisville prevailing 29-24.

Click or tap on See Matchup to reveal more.

Dimers has full betting coverage of this week's James Madison-Louisville matchup, including pregame predictions, computer picks, and live win probabilities.

Remember, DimersBOT updates frequently, so check this article for any changes to our betting insights ahead of James Madison vs. Louisville on Saturday November 5, 2022.

James Madison vs. Louisville 2022 CFB Game Info

Saturday's matchup between Louisville and James Madison in College Football at Cardinal Stadium is scheduled to begin at 7:30PM ET.

Who: James Madison vs. Louisville
Date: Saturday November 5, 2022
Time: 7:30PM ET / 4:30PM PT
Venue: Cardinal Stadium

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Kevin Hansen

Senior Sports Analyst

Kevin Hansen has a track record of delivering high-quality content. He writes about all sports, but his favorites are the NFL, NBA, MLB, and NHL. Kevin enjoys crunching the numbers and using data-driven insights to take on the sportsbooks. The majority of Kevin's time is spent writing about sports betting. His love for data and analytics drove him into the world of sports betting. Finding an edge in sports betting can take a long time, but Kevin believes it is well worth the effort. Kevin is just as passionate about sports as you are, and he empowers fellow bettors to become more educated through simple, actionable betting tips. It can be difficult to navigate the world of sports betting, which is where Kevin comes in to make it as simple as possible for you to pick a winner.