Jaguars vs. Bills Week 5 Prediction and Odds - October 8, 2023

The Buffalo Bills will take on the Jacksonville Jaguars in NFL Week 5 action at Tottenham Hotspur Stadium on Sunday, starting at 9:30AM ET.

Dimers' best betting picks for Jaguars vs. Bills, as well as game predictions, betting odds and touchdown scorer probabilities, are detailed in this article.

Today's Jacksonville vs. Buffalo betting analysis is sponsored by Bet365, which has an outstanding Bet $5, Get $150 in Bonus Bets offer for new customers.

Who Will Win: Jaguars vs. Bills

Based on cutting-edge computer power and data, Dimers.com has simulated Sunday's Jaguars-Bills NFL game 10,000 times.

Dimers' famous predictive analytics model, DimersBOT, currently gives the Bills a 68% chance of defeating the Jaguars in Week 5 of the NFL season.

More: Betting Analysis for Jaguars vs. Bills

Jaguars vs. Bills Odds

• Spread: Bills -5.5 (-104), Jaguars +5.5 (-110)
• Moneyline: Bills -240, Jaguars +205
• Total: Over/Under 48.5 (-110/-108)

The Bills are -5.5 favorites against the Jaguars, with -104 at FanDuel Sportsbook the best odds currently available.

For the underdog Jaguars (+5.5) to cover the spread, DraftKings Sportsbook has the best odds currently on offer at -110.

PointsBet currently has the best moneyline odds for the Bills at -240, which means you can risk $240 to win $100, for a total payout of $340, if they get the W.

Elsewhere, DraftKings Sportsbook currently has the best moneyline odds for the Jaguars at +205, where you can bet $100 to profit $205, earning a total payout of $305, if they win.

The Over/Under sits at 48.5 with PointsBet, which currently has the best odds for the Over at -110, while DraftKings Sportsbook currently has the best odds for the Under at -108.

As always, make sure you check the sportsbooks you have access to in your state for the best NFL odds and lines.

According to DimersBOT, the Jaguars (+5.5) have a 51% chance of covering the spread, while the 48.5-point Over/Under has a 53% chance of going Over.

Calling all football fans! If you are yet to sign up with DraftKings Sportsbook, today is the day! Click here to sign up, and then place a $5 wager on Jacksonville vs. Buffalo to receive $200 in bonus bets!

More: Predictions for Every NFL Week 5 Matchup

Best Bets: Jaguars vs. Bills

• Spread: Jaguars +5.5 @ -110 via DraftKings Sportsbook (51% probability)
• Moneyline: Jaguars @ +205 via DraftKings Sportsbook
• Total: Over 48.5 @ -110 via PointsBet (53% probability)

Our best bets are based on world-class simulations and wagering expertise to help you make better decisions with the legal sportsbooks in America.

While the Bills are more likely to win the game, according to DimersBOT, taking the Jaguars moneyline is the best option due to the edge found when comparing our data-led probabilities to the sportsbooks' odds currently on offer.

Taking advantage of the edges published here at Dimers is pivotal to being profitable in the long run.

Jaguars vs. Bills Prediction

Dimers.com's predicted final score for Jacksonville vs. Buffalo at Tottenham Hotspur Stadium in Week 5 has the Bills winning 27-22.

Click or tap on See Matchup to find out more.

Dimers has full betting coverage of this week's Jaguars-Bills game in Week 5, including pregame predictions, computer picks, and live win probabilities.

Jaguars vs. Bills Player Props

Who will score the first touchdown in Jaguars vs. Bills? The data is in.

Listed below are the most likely first touchdown and most likely anytime touchdown scorers for both the Jaguars and Bills, as well as player stat projections.

And you know what, we provide this information to you for FREE to help you select the best prop bets for Sunday's game.

According to DimersBOT, Buffalo's Stefon Diggs is most likely to score the first TD in Jaguars vs. Bills.

DimersBOT gives Diggs an 11.0% chance of scoring the first TD at Tottenham Hotspur Stadium, while the Bills WR is a 47.4% chance of scoring an anytime touchdown.

Scroll down for the full list of first and anytime TD scorer probabilities, which provide a great avenue for you to use this DraftKings Sportsbook offer, which unlocks $200 in bonus bets from a $5 bet on any of the below players.

First Touchdown Scorer Probabilities

Jacksonville Jaguars

• Calvin Ridley: 7.5% probability
• Travis Etienne: 7.3% probability
• Christian Kirk: 6.9% probability
• Evan Engram: 5.7% probability
• Trevor Lawrence: 5.0% probability

Buffalo Bills

• Stefon Diggs: 11.0% probability
• James Cook: 8.8% probability
• Josh Allen: 7.4% probability
• Gabe Davis: 6.5% probability
• Latavius Murray: 4.0% probability

Anytime Touchdown Scorer Probabilities

Jacksonville Jaguars

• Calvin Ridley: 35.3% probability
• Travis Etienne: 34.9% probability
• Christian Kirk: 32.9% probability
• Evan Engram: 28.9% probability
• Trevor Lawrence: 26.6% probability

Buffalo Bills

• Stefon Diggs: 47.4% probability
• James Cook: 39.8% probability
• Josh Allen: 35.2% probability
• Gabe Davis: 30.0% probability
• Latavius Murray: 20.2% probability

Jaguars-Bills Projected Player Stats

Of the starting quarterbacks, the Jaguars' Trevor Lawrence is projected for 241 passing yards. The Bills' Josh Allen is expected to throw for 239 yards.

Jaguars Starting QB

• Trevor Lawrence: 241 projected yards

Bills Starting QB

• Josh Allen: 239 projected yards

Jaguars Rushing

• Travis Etienne: 77 projected yards
• Trevor Lawrence: 19 projected yards
• Tank Bigsby: 11 projected yards

Bills Rushing

• James Cook: 70 projected yards
• Josh Allen: 33 projected yards
• Damien Harris: 26 projected yards

Jaguars Receiving

• Calvin Ridley: 58 projected yards
• Evan Engram: 53 projected yards
• Christian Kirk: 52 projected yards
• Zay Jones: 30 projected yards
• Travis Etienne: 22 projected yards

Bills Receiving

• Stefon Diggs: 88 projected yards
• Gabe Davis: 49 projected yards
• Dalton Kincaid: 32 projected yards
• Dawson Knox: 25 projected yards
• Trent Sherfield: 25 projected yards

Remember, DimersBOT updates frequently, so check this page for the latest betting insights ahead of Jaguars vs. Bills on Sunday October 8, 2023.

Jaguars vs. Bills 2023

The NFL Week 5 matchup between the Bills and Jaguars at Tottenham Hotspur Stadium is scheduled to begin at 9:30AM ET.

• Who: Jacksonville Jaguars vs. Buffalo Bills
• Date: Sunday October 8, 2023
• Time: 9:30AM ET / 6:30AM PT
• Venue: Tottenham Hotspur Stadium

Ready to join an online sportsbook and start betting on the NFL today? We've listed the best available welcome offers for each and every legal betting state, including Bet365, where you get $150 in bonus bets for signing up and bettting $5 on Jacksonville vs. Buffalo.

Make Smarter Sports Betting Decisions Today

Dimers' predictions are made after 10,000 simulations per game, using reliable and up-to-date data sources and analytical methods.

While our Jaguars vs. Bills picks can help you make informed decisions, it's crucial that you gamble responsibly and manage your bankroll effectively.

For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

What NFL Games Are on Today?

The Jaguars and Bills aren't the only two NFL teams you can bet on. DimersBOT never stops and we've got picks and top bets for each and every NFL matchup via our NFL predictions. Not only do we provide with you quality predictions, but we also have recommended bets for the Spread, Over/Under and Moneyline. Sound good? Hell yeah it does!

In addition to our leading NFL predictions, Dimers also offers the best NFL prop bets today, projecting passing yards, touchdowns, and more against the best odds available every day of the NFL season.