Jaguars vs. Colts Prediction: Indianapolis Predicted to Win in NFL Week 18 [2025]

The Indianapolis Colts will face the Jacksonville Jaguars in NFL Week 18 action at Lucas Oil Stadium on Sunday, beginning at 1:00PM ET.

Based on updated simulations, Dimers' advanced NFL model (see Dimers Pro for full access) projects the Colts as the most likely winner of today's game.

"Using the most recent data, our experts ran 10,000 simulations of Sunday's Jacksonville-Indianapolis game," said Dimers' Chief Content Officer, Nick Slade.

"After accounting for recent updates and other variables, our prediction shows the Colts with a win probability of 60%, while the Jaguars have 40%."

This updated Jaguars vs. Colts betting preview builds on my early Jaguars vs. Colts prediction that I released at the start of the week.

For further insights into today’s game, including the predicted score, best bets and player prop picks, visit our interactive Jaguars vs. Colts predictions page.

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Jaguars vs. Colts Game-Day Updates and Essential Details

The NFL Week 18 matchup between the Colts and Jaguars at Lucas Oil Stadium is scheduled to start at 1:00PM ET.

• Who: Jacksonville Jaguars vs. Indianapolis Colts
• Date: Sunday, January 5, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Lucas Oil Stadium
• Tickets: Get tickets for the game on Ticketmaster
• Merchandise: Buy Colts and Jaguars gear at Fanatics

Dimers.com's full preview of this week's Jaguars vs. Colts matchup includes our prediction, picks and the latest betting odds.

Before making any Jacksonville vs. Indianapolis picks, be sure to check out the latest NFL predictions and betting advice from Dimers Pro.

Jaguars vs. Colts Predictions

Using innovative machine learning and data, we have simulated the result of Sunday's NFL game between the Jaguars and Colts 10,000 times as part of our NFL predictions coverage.

Our famous predictive model gives the Colts a 60% chance of defeating the Jaguars in Week 18 of the NFL season. Our predicted final score has the Colts winning 24-21.

According to our model, the Jaguars (+3.5) have a 59% chance of covering the spread, while the over/under total of 46.5 points has an equal 50-50 chance of hitting.

Jaguars vs. Colts Odds

We have researched the best betting odds in America for this game, which are listed here:

Bet Type	Jaguars	Colts
Spread	+3.5 (-105)	-3.5 (-110)
Moneyline	+176	-180
Total	o46.5 (-105)	u46.5 (-115)

All odds are correct at the time of publication and are subject to change.

Jaguars vs. Colts Picks

Our model's biggest edge in today's Jaguars vs. Colts matchup is on the over/under.

Our expert predictions, aligned with the best odds, reveal the best NFL picks for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Jaguars vs. Colts TD Scorers

Who will score an anytime touchdown in Jaguars vs. Colts?

According to our model, Indianapolis' Jonathan Taylor is most likely to score the first TD in Jaguars vs. Colts.

Our projections give Taylor a 17.1% chance of getting in for six first at Lucas Oil Stadium, while the Colts RB is a 62.3% chance of scoring an anytime touchdown.

First Touchdown Scorer Predictions

Jacksonville Jaguars

Player	First TD Probability
Tank Bigsby	10.9%
Brian Thomas	8.9%
Travis Etienne	7.3%

Indianapolis Colts

Player	First TD Probability
Jonathan Taylor	17.1%
Josh Downs	7.5%
Michael Pittman	6.5%

Anytime Touchdown Scorer Predictions

Jacksonville Jaguars

Player	Anytime TD Probability
Tank Bigsby	44.9%
Brian Thomas	37.7%
Travis Etienne	32.2%

Indianapolis Colts

Player	Anytime TD Probability
Jonathan Taylor	62.3%
Josh Downs	33.4%
Michael Pittman	30.5%

Jaguars vs Colts Player Props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Jaguars and Colts. For detailed projections, join Dimers Pro.

Already a Dimers Pro member? Head to our Jaguars-Colts page now to access every player prop projection.

Jaguars vs. Colts Quarterbacks

Of the starting quarterbacks, the Jaguars' Mac Jones is projected to throw for fewer yards than the Colts' Joe Flacco.

Jaguars Rushing

Travis Etienne, Tank Bigsby and Mac Jones are projected to be the leading rushers for the Jaguars.

Player	Position
Travis Etienne	RB
Tank Bigsby	RB
Mac Jones	QB

Colts Rushing

Jonathan Taylor, Trey Sermon and Joe Flacco are expected to lead the Colts in rushing yards.

Player	Position
Jonathan Taylor	RB
Trey Sermon	RB
Joe Flacco	QB

Jaguars Receiving

Brian Thomas, Parker Washington, Brenton Strange, Travis Etienne and Luke Farrell are projected to top the receiving yards for the Jaguars.

Player	Position
Brian Thomas	WR
Parker Washington	WR
Brenton Strange	TE
Travis Etienne	RB
Luke Farrell	TE

Colts Receiving

Michael Pittman, Josh Downs, Alec Pierce, Adonai Mitchell and Jonathan Taylor are projected to lead the Colts in receiving yards.

Player	Position
Michael Pittman	WR
Josh Downs	WR
Alec Pierce	WR
Adonai Mitchell	WR
Jonathan Taylor	RB

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Conclusion

We predict the Colts, with a 60% win probability, will likely beat the Jaguars in Week 18 of the NFL season.

AI and automation have enhanced this article to quickly deliver accurate Jaguars vs. Colts insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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