Indiana vs. Purdue CFB Predictions and Odds - Nov 27, 2021

Purdue and Indiana meet in Week 13 of the College Football season at Ross-Ade Stadium on Saturday, starting at 3:30 PM EST.

Dimers' best betting picks for Indiana vs. Purdue, plus game predictions and best odds, are detailed below.

Who will win Indiana vs. Purdue?

Using cutting-edge machine learning and data, Dimers.com has simulated Saturday's Indiana-Purdue NCAA Football matchup 10,000 times.

Dimers' revolutionary predictive analytics model, DimersBOT, gives Purdue an 87% chance of defeating Indiana.

MORE: Indiana vs. Purdue Simulated 10,000 Times

Indiana vs. Purdue Point Spread, Moneyline and Over/Under

Purdue is the -18 favorite against Indiana, with -110 at DraftKings Sportsbook the best odds available.

For the underdog Indiana (+18) to cover the spread, DraftKings Sportsbook also has the best odds on offer at -110.

PointsBet has the best moneyline odds for Purdue at -630. That means you can risk $630 to win $100, for a total payout of $730, if it gets the W.

Elsewhere, Caesars Sportsbook has the best moneyline odds for Indiana at +600, where you can bet $100 to profit $600, earning a total payout of $700, if it wins.

The Over/Under for total points scored is set at 50.5 with Caesars Sportsbook, which has the best odds for the Over at -110, as well as the best odds for the Under at -110.

As always, check out the sportsbooks you have access to in your state for the best College Football odds and lines.

According to DimersBOT, Indiana (+18) is a 55% chance of covering the spread, while the 50.5-point Over/Under is a 53% chance of going Under.

MORE: Best Bets Today for All Major College Sports

Best Bets for Indiana vs. Purdue

• Spread: Indiana +18 at -110 with DraftKings Sportsbook (55% probability)
• Moneyline: Indiana Win at +600 with Caesars Sportsbook (1.7% edge)
• Over/Under: Under 50.5 at -110 with Caesars Sportsbook (53% probability)

While Purdue is more likely to win the game, according to DimersBOT, betting on Indiana moneyline is the best option due to the 1.7% edge found when comparing our data-led probabilities to the sportsbooks' odds.

Taking advantage of the edges published on Dimers is pivotal to achieving long-term profitability.

Indiana vs. Purdue Score Prediction

Dimers.com's predicted final score for Indiana vs. Purdue at Ross-Ade Stadium this Saturday has Purdue winning 34-17.

Use our dynamic widget below to see the latest Spread, Over/Under and Moneyline probabilities and odds for the game, and click or tap on See Matchup for more.

Dimers has full betting coverage of this week's Indiana-Purdue matchup, including pre-game predictions, computer picks, and live win probabilities.

Remember, DimersBOT updates often, so refresh this article for any changes to our betting insights ahead of Indiana vs. Purdue on Saturday November 27, 2021.

Indiana vs. Purdue 2021 CFB Game Info

When does Purdue play Indiana in College Football?

• Date: Saturday November 27, 2021
• Time: 3:30 PM EST / 12:30 PM PST
• Venue: Ross-Ade Stadium

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What other CFB games are on this week?

Indiana and Purdue aren't the only two NCAA Football teams you can bet on today. DimersBOT never stops and we've got picks and best bets for each and every CFB matchup in our College Football Bet Hub section.

Not only do we provide with you first-class predictions, but we also have recommended bets for the Spread, Over/Under and Moneyline. Sound good? Check it out now!