Houston vs. Duke Prediction: Duke Predicted to Win March Madness Final Four Matchup [4/5/2025]

Duke will face Houston in March Madness Final Four action at Alamodome on Saturday, commencing at 8:49PM ET.

Based on the latest simulation results, Dimers' advanced college basketball model (see Dimers Pro for full access) predicts Duke as the most likely winner of today's game.

Check the latest March Madness player prop projections and 2025 NCAA Championship probabilities, as well as the initial March Madness bracket projections from our expert team.

"Our team has used the latest data to run 10,000 simulations of Saturday's Houston-Duke game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various other inputs, we estimate that Duke is more likely to win, while Houston has a lower chance of victory."

For a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Houston vs. Duke predictions page.

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Houston vs. Duke Prediction: Who Will Win and Advance to the Championship Game?

Using powerful machine learning and data, we have simulated the result of Saturday's NCAA Tournament game between Houston and Duke 10,000 times as part of our March Madness predictions coverage.

Our independent predictive model gives Duke a 68% chance of defeating Houston. Our predicted final score has Duke winning 73-68.

According to our model, the bookmakers have got it right, and Houston and Duke each have a 50% chance of covering the spread, while the over/under total of 137.5 points has a 56% chance of going over.

Houston vs. Duke March Madness Odds

We have sourced the best March Madness odds in America for this Final Four game, which are listed here:

Bet Type	Houston	Duke
Spread	+4.5 (-105)	-4.5 (-110)
Moneyline	+220	-250
Total	o137.5 (-105)	u137.5 (-110)

All odds are correct at the time of publication and are subject to change.

Boost your betting this month with the top March Madness betting sites and March Madness betting promos, sourced from top sportsbooks and DFS operators.

Houston vs. Duke Picks and Best Bets

Our model's strongest edge in today's Houston vs. Duke matchup is on the spread.

Our expert predictions, matched against the latest odds, reveal the best March Madness picks and March Madness best bets for every game throughout the tournament.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Houston vs. Duke Game-Day Updates and Essential Details

Saturday's college basketball action between Duke and Houston at Alamodome is scheduled to begin at 8:49PM ET.

• Who: Houston vs. Duke
• Date: Saturday, April 5, 2025
• Time: 8:49PM ET/5:49PM PT
• Venue: Alamodome
• March Madness Stage: Final Four

Dimers.com's in-depth preview of Saturday's Houston vs. Duke matchup includes our prediction, picks and the latest betting odds.

Before making any Houston vs. Duke picks, be sure to check out the latest March Madness predictions and betting advice from Dimers Pro.

Key March Madness Guides and Insights

• Learn about NCAA Championship history and the lowest-seeded team to ever win March Madness
• Get answers to legal questions, including which states you can legally bet on college sports and the minimum age required to place a bet on March Madness
• A breakdown of March Madness futures bets and popular prop bets for the NCAA tournament
• Explore strategy with guides on identifying value bets during the tournament and betting on individual player awards like Tournament MVP
• Understand the tournament format, including how many games are played in March Madness and how venue locations impact teams when playing at neutral sites

Conclusion

We predict Duke, with a 68% win probability, will likely beat Houston on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Houston vs. Duke insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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