Astros vs. Cardinals Prediction: Houston Predicted to Win Monday's MLB Matchup [4/14/2025]

The St. Louis Cardinals will face the Houston Astros in MLB action at Busch Stadium on Monday, commencing at 7:45PM ET.

The Cardinals will have Sonny Gray (2-0, 4.50 ERA) as their starting pitcher, while the Astros will counter with Framber Valdez (1-1, 2.50 ERA).

Based on updated simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Astros as the most likely winner of today's game.

"Our team has utilized the latest data to simulate Monday's Houston-St. Louis game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"Incorporating recent updates and thousands of additional inputs, our prediction shows the Astros are likely to win, with a probability of 53%, compared to the Cardinals' 47%."

For further insights into Monday's matchup, including best bets and picks, visit our interactive Astros vs. Cardinals predictions page.

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Astros vs. Astros Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data, we have simulated the result of Monday's MLB game between the Astros and Cardinals 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Astros a 53% chance of beating the Cardinals.

According to our model, the Cardinals (+1.5) have a 61% chance of covering the run line, while the over/under total of 7 runs has a 51% chance of going over.

Pre-Game Probabilities

Last Updated: 11:27PM, Apr 14

Moneyline

Over / Under

Run Line

Astros

Win %

53%

47%

-108

-104

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Cardinals

Astros HOU

-108

Win %

53%

47%

See Matchup

Cardinals STL

-104

Framber Valdez 1-1, 2.50 ERA

Sonny Gray 2-0, 4.50 ERA

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Astros vs. Cardinals Odds [4/14/2025]

We have researched the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Astros vs. Cardinals Picks and Best Bets

Our model's strongest edge in today's Astros vs. Cardinals matchup is on the over/under.

Our expert predictions, aligned with the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Best Bets Video

Calling Our Shot produces daily MLB betting content, including the latest free picks featured below.

Astros vs. Cardinals Game-Day Updates and Essential Details

Monday's MLB matchup between the Cardinals and Astros at Busch Stadium is scheduled to commence at 7:45PM ET.

• Who: Houston Astros vs. St. Louis Cardinals
• Date: Monday, April 14, 2025
• Time: 7:45PM ET/4:45PM PT
• Venue: Busch Stadium

Dimers.com's comprehensive preview of Monday's Astros vs. Cardinals matchup includes our prediction, picks and the latest betting odds.

Before making any Houston vs. St. Louis picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Astros, with a 53% win probability, will likely beat the Cardinals on Monday.

AI and automation have enhanced this article to quickly deliver accurate Astros vs. Cardinals insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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