Astros vs. Mariners Prediction: Houston Predicted to Win Wednesday's MLB Matchup [4/9/2025]

The Seattle Mariners will take on the Houston Astros in MLB action at T-Mobile Park on Wednesday, beginning at 4:10PM ET.

Luis F. Castillo (0-0, 9.00 ERA) will be on the bump for the Mariners, up against Hunter Brown (1-1, 3.00 ERA) for the Astros.

Based on updated simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Astros as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's Houston-Seattle game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Astros' chance of winning at 56%, with the Mariners at 44%."

For expanded analysis of Wednesday's matchup, including best bets and picks, visit our interactive Astros vs. Mariners predictions page.

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Astros vs. Astros Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and statistical analysis, we have simulated the result of Wednesday's MLB matchup between the Astros and Mariners 10,000 times as part of our MLB predictions coverage.

Our leading predictive model currently gives the Astros a 56% chance of beating the Mariners.

According to our model, the Mariners (+1.5) have a 58% chance of covering the run line, while the over/under total of 7.5 runs has an equal 50-50 chance of hitting.

Pre-Game Probabilities

Last Updated: 8:28PM, Apr 9

Moneyline

Over / Under

Run Line

Astros

Win %

57%

43%

-140

+125

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Mariners

Astros HOU

-140

Win %

57%

43%

See Matchup

Mariners SEA

+125

Hunter Brown 1-1, 3.00 ERA

Luis Castillo 0-0, 9.00 ERA

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Astros vs. Mariners Odds [4/9/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Astros vs. Mariners Picks and Best Bets

Our model's strongest edge in today's Astros vs. Mariners matchup is on the run line.

Our expert predictions, matched against the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Best Bets Video

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

Astros vs. Mariners Game-Day Updates and Essential Details

Wednesday's MLB matchup between the Mariners and Astros at T-Mobile Park is scheduled to start at 4:10PM ET.

• Who: Houston Astros vs. Seattle Mariners
• Date: Wednesday, April 9, 2025
• Time: 4:10PM ET/1:10PM PT
• Venue: T-Mobile Park

Dimers.com's full preview of Wednesday's Astros vs. Mariners matchup includes our prediction, picks and the latest betting odds.

Before making any Houston vs. Seattle picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Astros, with a 56% win probability, will likely beat the Mariners on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Astros vs. Mariners insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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