Astros vs. Twins Prediction: Minnesota Predicted to Win Saturday's MLB Matchup [4/5/2025]

The Minnesota Twins and Houston Astros are scheduled to meet in MLB action at Target Field on Saturday, starting at 2:10PM ET.

The Twins will send Bailey Ober (0-1, 27.00 ERA) to the mound, while the Astros have opted for Spencer Arrighetti (1-0, 1.50 ERA).

Based on the latest simulations, Dimers' advanced MLB model (see Dimers Pro for full access) projects the Twins as the most likely winner of today's game.

"Our team has used the latest data to run 10,000 simulations of Saturday's Houston-Minnesota game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various other inputs, we estimate that the Twins are more likely to win, while the Astros have a lower chance of victory."

For a closer look at Saturday's matchup, including best bets and picks, visit our interactive Astros vs. Twins predictions page.

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Astros vs. Astros Prediction: Who Will Win, Cover the Run Line?

Using innovative machine learning and data, we have simulated the outcome of Saturday's MLB matchup between the Astros and Twins 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Twins a 53% chance of defeating the Astros.

According to our model, the Astros (+1.5) have a 66% chance of covering the run line, while the 7.5-run over/under has a 56% chance of going over.

Pre-Game Probabilities

Last Updated: 6:28PM, Apr 5

Moneyline

Over / Under

Run Line

Astros

Win %

48%

52%

+112

-125

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Twins

Astros HOU

+112

Win %

48%

52%

See Matchup

Twins MIN

-125

Spencer Arrighetti 1-0, 1.50 ERA

Bailey Ober 0-1, 27.00 ERA

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Astros vs. Twins Odds [4/5/2025]

We have researched the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

Astros vs. Twins Picks and Best Bets

Our model's biggest edge in today's Astros vs. Twins matchup is on the run line.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Astros vs. Twins Game-Day Updates and Essential Details

Saturday's MLB matchup between the Twins and Astros at Target Field is scheduled to begin at 2:10PM ET.

• Who: Houston Astros vs. Minnesota Twins
• Date: Saturday, April 5, 2025
• Time: 2:10PM ET/11:10AM PT
• Venue: Target Field

Dimers.com's comprehensive preview of Saturday's Astros vs. Twins matchup includes our prediction, picks and the latest betting odds.

Before making any Houston vs. Minnesota picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Conclusion

We predict the Twins, with a 53% win probability, will likely beat the Astros on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Astros vs. Twins insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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