Astros vs. Royals Prediction: Houston Predicted to Win Friday's MLB Matchup [4/25/2025]

The Kansas City Royals will square off with the Houston Astros, in what is expected to be a close MLB game, at Kauffman Stadium on Friday, starting at 7:40PM ET.

The Royals will have Seth Lugo (1-3, 3.90 ERA) as their starting pitcher, up against Hayden Wesneski (1-1, 3.91 ERA) for the Astros.

Based on the latest simulations, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Astros as the most likely winner of today's game.

"Employing the latest data, our experts simulated Friday's Houston-Kansas City game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"After computing the latest updates and thousands of other inputs, we predict the Astros' chance of winning is 53%, while the Royals' is 47%."

For expanded analysis of Friday's matchup, including best bets and picks, visit our interactive Astros vs. Royals predictions page.

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Royals vs. Astros Prediction: Who Will Win, Cover the Run Line?

Using trusted machine learning and data analysis, we have simulated the result of Friday's MLB matchup between the Astros and Royals 10,000 times as part of our MLB predictions coverage.

Our famous predictive model currently gives the Astros a 53% chance of beating the Royals.

According to our model, the Royals (+1.5) have a 60% chance of covering the run line, while the 8-run over/under has a 51% chance of going over.

Pre-Game Probabilities

Last Updated: 11:28PM, Apr 25

Moneyline

Over / Under

Run Line

Astros

Win %

53%

47%

-112

+100

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Royals

Astros HOU

-112

Win %

53%

47%

See Matchup

Royals KC

+100

Hayden Wesneski 1-1, 3.91 ERA

Seth Lugo 1-3, 3.90 ERA

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Astros vs. Royals Odds [4/25/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

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Astros vs. Royals Picks and Best Bets

Our model's biggest edge in today's Astros vs. Royals matchup is on the total.

Our expert predictions, matched against the current odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

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Calling Our Shot's Best Bets Today

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Astros vs. Royals Game-Day Updates and Essential Details

Friday's MLB game between the Royals and Astros at Kauffman Stadium is scheduled to begin at 7:40PM ET.

• Who: Houston Astros vs. Kansas City Royals
• Date: Friday, April 25, 2025
• Time: 7:40PM ET/4:40PM PT
• Venue: Kauffman Stadium

Dimers.com's comprehensive preview of Friday's Astros vs. Royals matchup includes our prediction, picks and the latest betting odds.

Before making any Houston vs. Kansas City picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Astros, with a 53% win probability, will likely beat the Royals on Friday.

AI and automation have enhanced this article to quickly deliver accurate Astros vs. Royals insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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