Holger Rune vs. Reilly Opelka Prediction, Odds, Picks for ATP Miami Open 2025

Holger Rune and Reilly Opelka will meet in the round of 64 of the ATP Miami Open event on Saturday.

Based on the latest simulations, Dimers' advanced tennis model (see Dimers Pro for full access) projects Holger Rune as the most likely winner of the match.

"We have used the latest data to run 10,000 simulations of Saturday's Rune-Opelka match," said Dimers data analyst Greg Butyn.

"By incorporating recent updates and various other inputs, we estimate that Holger Rune is more likely to win, while Reilly Opelka has a lower chance of victory."

For a closer look at Saturday's match, including best bets and picks, visit our interactive Rune vs. Opelka predictions page.

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Rune vs. Opelka Prediction: Who Will Win?

Using powerful machine learning and data analysis, we have simulated the result of Saturday's Rune-Opelka men's singles match 10,000 times as part of our tennis predictions coverage.

Our leading predictive model gives Rune a 62% chance of defeating Opelka at the ATP Miami Open tournament.

Additionally, Rune has a 59% chance of winning the first set, according to our model.

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Holger Rune vs. Reilly Opelka Odds

We have sourced the most up-to-date betting odds in America for this match, which are listed here:

Bet Type	Rune	Opelka
Moneyline	-250	+200
First Set	-200	+162

All odds are correct at the time of publication and are subject to change.

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Rune vs. Opelka Picks and Best Bets

Our model's strongest edge in today's Rune vs. Opelka match is on the moneyline.

Our expert predictions, aligned with the current odds, reveal the best tennis picks and tennis best bets for every tournament throughout the year.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Rune vs. Opelka Updates and Essential Details

The ATP Miami Open match between Holger Rune and Reilly Opelka is scheduled to commence on Saturday at 4:15PM ET.

• Who: Holger Rune vs. Reilly Opelka
• Date: Saturday, March 22, 2025
• Approx. Time: 4:15PM ET/1:15PM PT
• Tournament: ATP Miami, USA Men's Singles 2025
• Round: Round of 64

All dates and times mentioned in this article are United States Eastern Time unless otherwise noted.

Dimers.com's in-depth preview of Saturday's Rune vs. Opelka match includes our prediction, picks and the latest betting odds.

Before making any Holger Rune vs. Reilly Opelka picks, be sure to check out the latest tennis predictions and betting advice from Dimers Pro.

Conclusion

We predict Holger Rune, with a 62% win probability, will likely beat Reilly Opelka at the ATP Miami Open tournament.

AI and automation have enhanced this article to quickly deliver accurate Rune vs. Opelka insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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