Guardians vs. Yankees Prediction and Odds - Apr 23, 2022

MLB action continues on Saturday at 1:05PM ET as the Cleveland Guardians take on the New York Yankees at Yankee Stadium.

The Yankees will have Nestor Cortes Jr. (0-0, 0.00 ERA) start, pitting him against Cal Quantrill (1-0, 3.72 ERA) for the Guardians.

Dimers' top betting picks for Guardians vs. Yankees, as well as game predictions and best odds, are detailed in this article.

Who will win Guardians vs. Yankees?

Based on cutting-edge machine learning and data, Dimers.com has simulated Saturday's Guardians-Yankees MLB matchup 10,000 times.

Dimers' leading predictive analytics model, DimersBOT, gives the Yankees a 62% chance of beating the Guardians.

More: Full Betting Guide for Guardians vs. Yankees

Guardians vs. Yankees Game Odds

• Run Line: Yankees -1.5 (+115), Guardians +1.5 (-125)
• Moneyline: Yankees -180, Guardians +175
• Total: Over/Under 7.5 (-110/-105)

Run Line, Moneyline and Over/Under

The Yankees are listed as -1.5 favorites against the Guardians, with +115 at DraftKings Sportsbook the best odds currently available.

For the underdog Guardians (+1.5) to cover the run line, BetMGM has the best odds currently on offer at -125.

DraftKings Sportsbook currently has the best moneyline odds for the Yankees at -180, which means you can risk $180 to win $100, for a total payout of $280, if they get the W.

On the other hand, Caesars Sportsbook currently has the best moneyline odds for the Guardians at +175, where you can bet $100 to profit $175, earning a total payout of $275, if they win.

The Over/Under sits at 7.5 with Caesars Sportsbook, which currently has the best odds for the Over at -110, while BetMGM currently has the best odds for the Under at -105.

As always, make sure you check all the online sportsbooks that are available in your state for the best MLB odds and lines.

According to DimersBOT, the Guardians (+1.5) are a 57% chance of covering the run line, while the 7.5-run Over/Under is a 55% chance of going Over.

More: Best Bets for Every MLB Game

Best Bets for Guardians vs. Yankees

• Run Line: Guardians +1.5 @ -125 via BetMGM (57% probability)
• Moneyline: Guardians @ +175 via Caesars Sportsbook (2.1% edge)
• Total: Over 7.5 @ -110 via Caesars Sportsbook (55% probability)

Dimers' best bets are based on detailed simulations and betting intelligence to bring you the best possible plays every day of the year.

While the Yankees are more likely to win the game, according to DimersBOT, taking the Guardians moneyline is the best option because of the 2.1% edge identified when comparing our data-led probabilities to the betting odds currently available.

Taking advantage of the edges seen on Dimers is pivotal to achieving long-term profitability as a bettor.

Guardians vs. Yankees Probabilities

Use our dynamic widget below to view the latest Moneyline, Over/Under and Run Line probabilities and odds for Cleveland vs. NY Yankees, and click or tap on See Matchup for more.

Dimers has full coverage of Saturday's Guardians-Yankees matchup, including pregame predictions, free betting picks, and live scores.

Remember, DimersBOT updates frequently, so check this article for the latest betting insights before Guardians vs. Yankees on Saturday April 23, 2022.

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Guardians vs. Yankees 2022 Game Info

When do the Yankees play the Guardians?

• Date: Saturday April 23, 2022
• Time: 1:05PM ET / 10:05AM PT
• Venue: Yankee Stadium

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What MLB games are on today?

The Guardians and Yankees aren't the only two MLB teams you can bet on today. DimersBOT never stops and we've got picks and best bets for each and every MLB game via our MLB Predictions page.

Not only do we provide with you quality predictions, but we also have recommended bets for the Run Line, Over/Under and Moneyline. Sound good? Check it out now!

Finally, Dimers' Baseball Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities matched against the best odds available.