Guardians vs. White Sox Prediction and Odds - Sep 21, 2022

The Chicago White Sox take on the Cleveland Guardians in MLB action at Guaranteed Rate Field on Wednesday, commencing at 8:10PM ET.

Lance Lynn (7-5, 3.99 ERA) will be on the bump for the White Sox, while the Guardians are going with Triston McKenzie (10-11, 3.08 ERA).

Dimers' free betting picks for Guardians vs. White Sox, as well as game predictions and best odds, are detailed in this article.

Who will win Guardians vs. White Sox?

Based on high-tech machine learning and data, Dimers.com has simulated Wednesday's Guardians-White Sox MLB matchup 10,000 times.

Dimers' proven predictive analytics model, DimersBOT, currently gives the White Sox a 56% chance of defeating the Guardians.

More: Full Betting Analysis for Guardians vs. White Sox

Guardians vs. White Sox Game Odds

• Run Line: White Sox -1.5 (+158), Guardians +1.5 (-180)
• Moneyline: White Sox -134, Guardians +115
• Total: Over/Under 8 (-110/+105)

Run Line, Moneyline and Over/Under

The White Sox are listed as -1.5 favorites versus the Guardians, with +158 at Caesars Sportsbook the best odds currently available.

For the underdog Guardians (+1.5) to cover the run line, DraftKings Sportsbook has the best odds currently on the market at -180.

FanDuel Sportsbook currently has the best moneyline odds for the White Sox at -134, which means you can risk $134 to win $100, for a total payout of $234, if they get the W.

Elsewhere, DraftKings Sportsbook currently has the best moneyline odds for the Guardians at +115, where you can bet $100 to profit $115, earning a total payout of $215, if they win.

The Over/Under for total runs scored is set at 8 with BetMGM, which currently has the best odds for the Over at -110, while Caesars Sportsbook currently has the best odds for the Under at +105.

As always, check out all the sportsbooks that are available in your state for the best MLB odds and lines.

According to DimersBOT, the Guardians (+1.5) are a 62% chance of covering the run line, while the Over/Under total of 8 runs is a 57% chance of going Over.

More: Predictions for Every MLB Matchup

Best Bets for Guardians vs. White Sox

• Run Line: White Sox -1.5 @ +158 via Caesars Sportsbook
• Moneyline: White Sox @ -134 via FanDuel Sportsbook (56% probability)
• Total: Over 8 @ -110 via BetMGM (57% probability) 🔥

When you see a 🔥, you know you've found one of our best free picks of the day across all sports.

Our best bets are based on detailed simulations and wagering expertise to serve you the best possible plays 24/7.

Even though the Guardians are more likely to cover the run line, our best bet of White Sox -1.5 is based on the expectation of that happening, according to DimersBOT, and the best odds available.

Guardians vs. White Sox Betting Guide

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Dimers has full betting coverage of Wednesday's Guardians-White Sox matchup, including pregame predictions, free picks, and live win probabilities.

Don't forget, DimersBOT updates frequently, so keep an eye on this page for the latest betting insights before Guardians vs. White Sox on Wednesday September 21, 2022.

Guardians vs. White Sox 2022 Game Info

Wednesday's matchup between the White Sox and Guardians at Guaranteed Rate Field is scheduled to commence at 8:10PM ET.

• Who: Cleveland Guardians vs. Chicago White Sox
• Date: Wednesday September 21, 2022
• Time: 8:10PM ET / 5:10PM PT
• Venue: Guaranteed Rate Field

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