Guardians vs. White Sox Prediction and Odds - Jul 22, 2022

The Chicago White Sox take on the Cleveland Guardians in MLB action at Guaranteed Rate Field on Friday, starting at 8:10PM ET.

The White Sox will send Lucas Giolito (6-5, 4.69 ERA) to the mound, while the Guardians are going with Cal Quantrill (6-5, 3.76 ERA).

Dimers' best betting picks for Guardians vs. White Sox, plus game predictions and betting odds, are featured in this article.

Who will win Guardians vs. White Sox?

Using state-of-the-art machine learning and data, Dimers.com has simulated Friday's Guardians-White Sox MLB game 10,000 times.

Dimers' renowned predictive analytics model, DimersBOT, currently gives the White Sox a 58% chance of defeating the Guardians.

More: Full Betting Analysis for Guardians vs. White Sox

Guardians vs. White Sox Current Odds

• Run Line: White Sox -1.5 (+130), Guardians +1.5 (-145)
• Moneyline: White Sox -154, Guardians +142
• Total: Over/Under 8.5 (+100/-110)

Run Line, Moneyline and Over/Under

The White Sox are -1.5 favorites versus the Guardians, with +130 at Caesars Sportsbook the best odds currently available.

For the underdog Guardians (+1.5) to cover the run line, PointsBet has the best odds currently on offer at -145.

Caesars Sportsbook currently has the best moneyline odds for the White Sox at -154, which means you can risk $154 to win $100, for a total payout of $254, if they get the W.

Meanwhile, FanDuel Sportsbook currently has the best moneyline odds for the Guardians at +142, where you can bet $100 to profit $142, earning a total payout of $242, if they win.

The Over/Under for total runs scored sits at 8.5 with PointsBet, which currently has the best odds for the Over at +100, while FanDuel Sportsbook currently has the best odds for the Under at -110.

As always, check out all the sportsbooks available in your state for the best MLB odds and lines.

According to DimersBOT, the Guardians (+1.5) are a 60% chance of covering the run line, while the 8.5-run Over/Under is a 53% chance of going Over.

More: Live Win Probabilities for All Major Sports

Best Bets for Guardians vs. White Sox

• Run Line: Guardians +1.5 @ -145 via PointsBet (60% probability)
• Moneyline: Guardians @ +142 via FanDuel Sportsbook (1.0% edge)
• Total: Over 8.5 @ +100 via PointsBet (53% probability)

Our best bets are based on complex modeling and gambling expertise to serve you the best possible plays 24/7.

While the White Sox are more likely to win the game, according to DimersBOT, betting on the Guardians moneyline is the best option because of the 1.0% edge identified when comparing our data-led probabilities to the sportsbooks' odds currently available.

Taking advantage of the edges seen on Dimers.com is one of the keys to being profitable in the long run.

Guardians vs. White Sox Prediction

Use our dynamic widget below to explore the latest Moneyline, Over/Under and Run Line probabilities and odds for Cleveland vs. CHI White Sox, and click or tap on See Matchup to reveal more.

Dimers has full betting coverage of Friday's Guardians-White Sox matchup, including pregame predictions, free picks, and live scores.

Don't forget, DimersBOT updates often, so check this page for the latest betting analysis ahead of Guardians vs. White Sox on Friday July 22, 2022.

Claim Your Risk-Free Bet for Guardians vs. White Sox

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All you need to do is click or tap on this exclusive FanDuel Sportsbook link and create an account – it's easy and takes less than 2 minutes.

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Guardians vs. White Sox 2022 Game Info

Friday's matchup between the White Sox and Guardians at Guaranteed Rate Field is scheduled to begin at 8:10PM ET.

• Who: Chicago White Sox vs. Cleveland Guardians
• Date: Friday July 22, 2022
• Time: 8:10PM ET / 5:10PM PT
• Venue: Guaranteed Rate Field

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What other MLB games are on today?

The Guardians and White Sox aren't the only two MLB teams you can bet on. DimersBOT never stops and we've got picks and best bets for every single MLB game via our MLB Predictions section.

Not only do we provide with you first-class predictions, but we also have recommended bets for the Run Line, Over/Under and Moneyline. Sound good? Hell yeah it does!

While you're here, Dimers' MLB Futures page is our in-house approach to revealing who will win the 2022 World Series, with our data-led probabilities matched against the best odds to win the World Series.