Guardians vs. Padres Prediction and Odds - Aug 24, 2022

The San Diego Padres face the Cleveland Guardians in MLB action at PETCO Park on Wednesday, beginning at 4:10PM ET.

The Padres will have Blake Snell (5-6, 3.76 ERA) start, pitting him against Cal Quantrill (9-5, 3.77 ERA) for the Guardians.

Dimers' top betting picks for Guardians vs. Padres, as well as game predictions and betting odds, are detailed in this article.

Who will win Guardians vs. Padres?

Based on advanced computer power and data, Dimers.com has simulated Wednesday's Guardians-Padres MLB game 10,000 times.

Dimers' revolutionary predictive analytics model, DimersBOT, gives the Padres a 60% chance of defeating the Guardians.

More: Free Betting Guide for Guardians vs. Padres

Guardians vs. Padres Odds

• Run Line: Padres -1.5 (+135), Guardians +1.5 (-150)
• Moneyline: Padres -165, Guardians +145
• Total: Over/Under 7.5 (+100/-112)

Run Line, Moneyline and Over/Under

The Padres are listed as -1.5 favorites versus the Guardians, with +135 at PointsBet the best odds currently available.

For the underdog Guardians (+1.5) to cover the run line, BetMGM has the best odds currently on the market at -150.

BetMGM currently has the best moneyline odds for the Padres at -165, which means you can risk $165 to win $100, for a total payout of $265, if they get the W.

Meanwhile, PointsBet currently has the best moneyline odds for the Guardians at +145, where you can put down $100 to profit $145, earning a total payout of $245, if they win.

The Over/Under is set at 7.5 with BetMGM, which currently has the best odds for the Over at +100, while FanDuel Sportsbook currently has the best odds for the Under at -112.

As always, make sure you check the sportsbooks you have access to in your state for the best MLB odds and lines.

According to DimersBOT, the Guardians (+1.5) are a 58% chance of covering the run line, while the 7.5-run Over/Under is a 51% chance of going Over.

More: Live Win Probabilities for All Major Sports

Best Bets for Guardians vs. Padres

• Run Line: Padres -1.5 @ +135 via PointsBet
• Moneyline: Guardians @ +145 via PointsBet
• Total: Over 7.5 @ +100 via BetMGM (51% probability)

Our best bets are based on detailed modeling and betting intelligence to help you make better decisions with your state's legal sportsbooks.

Although the Guardians are more likely to cover the run line, our best bet of Padres -1.5 is based on the likelihood of that happening, according to DimersBOT, and the top odds available.

And while the Padres are more likely to win the game, according to DimersBOT, taking the Guardians moneyline is the best option because of the edge found when comparing our data-led probabilities to the betting odds currently on offer.

Taking advantage of the edges published on Dimers is pivotal to achieving long-term profitability as a bettor.

Guardians vs. Padres Prediction

Use our dynamic widget below to view up-to-date Moneyline, Over/Under and Run Line probabilities and odds for Cleveland vs. San Diego, and click or tap on See Matchup for more.

Dimers has full coverage of Wednesday's Guardians-Padres matchup, including pregame predictions, best betting picks, and live win probabilities.

Remember, DimersBOT updates regularly, so keep checking this page for any changes to our betting analysis ahead of Guardians vs. Padres on Wednesday August 24, 2022.

Best Sportsbook Promo for Guardians vs. Padres

Looking for the best sportsbook promo in America for Cleveland vs. San Diego? Join FanDuel Sportsbook now and get a risk-free first bet up to $1,000, which you can use on Wednesday's Guardians-Padres matchup.

Simply click or tap on this exclusive FanDuel Sportsbook link and create a new account – it's easy and takes less than 2 minutes.

Then, make your first deposit and place a bet up to $1K on Guardians vs. Padres. If you don't win your bet, FanDuel Sportsbook will give it back to you in site credit!

This promo is available to all new FanDuel Sportsbook users. How good is that!

Note: When you click or tap on a link on Dimers that goes to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee. Thank you for supporting the sponsors who make Dimers possible.

Guardians vs. Padres 2022 Game Info

Wednesday's matchup between the Padres and Guardians at PETCO Park is scheduled to begin at 4:10PM ET.

• Who: San Diego Padres vs. Cleveland Guardians
• Date: Wednesday August 24, 2022
• Time: 4:10PM ET / 1:10PM PT
• Venue: PETCO Park

Want to join an online sportsbook and start betting on MLB now? Check out the best sportsbook sign-up offers in your state.

What other MLB games are on today?

The Guardians and Padres aren't the only two MLB teams you can bet on today. DimersBOT never stops and we've got picks and top bets for each and every MLB game in our MLB Bet Hub page.

Not only do we provide with you top-notch predictions, but we also have recommended bets for the Run Line, Over/Under and Moneyline. Sound good? Check it out now!

Lastly, Dimers' MLB Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities matched against the best odds on the market.