Guardians vs. Astros Prediction and Odds - May 24, 2022

The Houston Astros and Cleveland Guardians are scheduled to meet in MLB at Minute Maid Park on Tuesday, starting at 8:10PM ET.

Framber Valdez (3-2, 2.68 ERA) will be on the bump for the Astros, up against Zach Plesac (1-3, 4.42 ERA) for the Guardians.

Dimers' best betting picks for Guardians vs. Astros, as well as game predictions and best odds, are featured in this article.

This Cleveland vs. Houston betting preview is presented by PointsBet, which has a great 5x $100 Risk-Free Bets offer for new users.

Who will win Guardians vs. Astros?

Using advanced machine learning and data, Dimers.com has simulated Tuesday's Guardians-Astros MLB game 10,000 times.

Dimers' proven predictive analytics model, DimersBOT, gives the Astros a 66% chance of winning against the Guardians.

More: Full Betting Guide for Guardians vs. Astros

Guardians vs. Astros Odds

• Run Line: Astros -1.5 (-102), Guardians +1.5 (-115)
• Moneyline: Astros -222, Guardians +194
• Total: Over/Under 8 (-115/+100)

Run Line, Moneyline and Over/Under

The Astros are -1.5 favorites versus the Guardians, with -102 at FanDuel Sportsbook the best odds currently available.

For the underdog Guardians (+1.5) to cover the run line, Caesars Sportsbook has the best odds currently on offer at -115.

Caesars Sportsbook currently has the best moneyline odds for the Astros at -222, which means you can risk $222 to win $100, for a total payout of $322, if they get the W.

On the other hand, FanDuel Sportsbook currently has the best moneyline odds for the Guardians at +194, where you can bet $100 to profit $194, earning a total payout of $294, if they win.

The Over/Under for total runs scored sits at 8 with Caesars Sportsbook, which currently has the best odds for the Over at -115, while DraftKings Sportsbook currently has the best odds for the Under at +100.

As always, make sure you check all the online sportsbooks available in your state for the best MLB odds and lines.

According to DimersBOT, the Guardians (+1.5) are a 52% chance of covering the run line, while the Over/Under total of 8 runs is a 54% chance of going Over.

More: Free Prop Picks

Best Bets for Guardians vs. Astros

• Run Line: Guardians +1.5 @ -115 via Caesars Sportsbook (52% probability)
• Moneyline: Guardians @ +194 via FanDuel Sportsbook
• Total: Over 8 @ -115 via Caesars Sportsbook (54% probability)

Dimers' best bets are based on detailed simulations and betting intelligence to bring you the best possible plays every time.

While the Astros are more likely to win the game, according to DimersBOT, taking the Guardians moneyline is the best option due to the edge identified when comparing our data-led probabilities to the betting odds currently available.

Taking advantage of the edges published on Dimers.com is crucial to achieving long-term profitability.

Guardians vs. Astros Betting Guide

Use our dynamic widget below to see up-to-date Moneyline, Over/Under and Run Line probabilities and odds for Cleveland vs. Houston, and click or tap on See Matchup for more.

Dimers has full coverage of Tuesday's Guardians-Astros matchup, including pregame predictions, free betting picks, and live win probabilities.

Remember, DimersBOT updates frequently, so refresh this page for the latest betting insights before Guardians vs. Astros on Tuesday May 24, 2022.

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Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Guardians vs. Astros 2022 Game Info

Tuesday's action between the Astros and Guardians at Minute Maid Park is scheduled to begin at 8:10PM ET.

• Who: Houston Astros vs. Cleveland Guardians
• Date: Tuesday May 24, 2022
• Time: 8:10PM ET / 5:10PM PT
• Venue: Minute Maid Park

Want to join an online sportsbook and start betting on MLB? We've reviewed the best available sign-up offers in each and every legal betting state.

What MLB games are on today?

Now you've got the 411 on Guardians vs. Astros, take a look at the latest betting coverage for all upcoming MLB games in Dimers' MLB Bet Hub, where you can find probabilities and odds, and our best bets for every single MLB matchup.

Want a pick for the Run Line? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!

Lastly, Dimers' Baseball Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities compared to the best odds on the market.