Gonzaga vs. Houston Prediction: Houston Predicted to Win March Madness Second Round Matchup [3/22/2025]

Houston and Gonzaga will lock horns in March Madness Second Round action at INTRUST Bank Arena on Saturday, starting at 8:40PM ET.

Based on updated simulation results, Dimers' proven college basketball model (see Dimers Pro for full access) predicts Houston as the most likely winner of today's game.

Check the latest March Madness bracket projections and 2025 NCAA Championship probabilities from our expert team.

"Our team has used the latest data to run 10,000 simulations of Saturday's Gonzaga-Houston game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various other inputs, we estimate that Houston is more likely to win, while Gonzaga has a lower chance of victory."

For a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Gonzaga vs. Houston predictions page.

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Gonzaga vs. Houston Prediction: Who Will Win and Advance to the Sweet Sixteen?

Using innovative machine learning and statistical analysis, we have simulated the outcome of Saturday's NCAA Tournament matchup between Gonzaga and Houston 10,000 times as part of our March Madness predictions coverage.

Our leading predictive model gives Houston a 70% chance of beating Gonzaga. Our predicted final score has Houston winning 73-68.

According to our model, the bookies have got it right, and Gonzaga and Houston each have a 50% chance of covering the spread, while the over/under total of 140.5 points has a 51% chance of staying under.

Gonzaga vs. Houston March Madness Odds

We have researched the best March Madness odds in America for this Second Round game, which are listed here:

Bet Type	Gonzaga	Houston
Spread	+5.5 (-110)	-5.5 (-110)
Moneyline	+195	-218
Total	o140.5 (-115)	u140.5 (-105)

All odds are correct at the time of publication and are subject to change.

Boost your betting this month with the top March Madness betting sites and March Madness betting promos, sourced from top sportsbooks and DFS operators.

Gonzaga vs. Houston Picks and Best Bets

Our model's biggest edge in today's Gonzaga vs. Houston matchup is on the moneyline.

Our expert predictions, matched against the current odds, reveal the best March Madness picks and March Madness best bets for every game throughout the tournament.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Gonzaga vs. Houston Game-Day Updates and Essential Details

Saturday's college basketball matchup between Houston and Gonzaga at INTRUST Bank Arena is scheduled to commence at 8:40PM ET.

• Who: Gonzaga vs. Houston
• Date: Saturday, March 22, 2025
• Time: 8:40PM ET/5:40PM PT
• Venue: INTRUST Bank Arena
• March Madness Stage: Second Round

Dimers.com's full preview of Saturday's Gonzaga vs. Houston matchup includes our prediction, picks and the latest betting odds.

Before making any Gonzaga vs. Houston picks, be sure to check out the latest March Madness predictions and betting advice from Dimers Pro.

Key March Madness Guides and Insights

• Learn about NCAA Championship history and the lowest-seeded team to ever win March Madness
• Get answers to legal questions, including which states you can legally bet on college sports and the minimum age required to place a bet on March Madness
• A breakdown of March Madness futures bets and popular prop bets for the NCAA tournament
• Explore strategy with guides on identifying value bets during the tournament and betting on individual player awards like Tournament MVP
• Understand the tournament format, including how many games are played in March Madness and how venue locations impact teams when playing at neutral sites

Conclusion

We predict Houston, with a 70% win probability, will likely beat Gonzaga on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Gonzaga vs. Houston insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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