Giants vs. Padres Prediction and Odds - Oct 4, 2022

The San Diego Padres square off with the San Francisco Giants in MLB action at PETCO Park on Tuesday, beginning at 9:40PM ET.

The Padres will have Sean Manaea (7-9, 5.15 ERA) start, pitting him against Alex Cobb (7-7, 3.80 ERA) for the Giants.

Dimers' top betting picks for Giants vs. Padres, as well as game predictions and best odds, are detailed in this article.

Who will win Giants vs. Padres?

Using high-tech computer power and data, Dimers.com has simulated Tuesday's Giants-Padres MLB matchup 10,000 times.

Dimers' independent predictive analytics model, DimersBOT, gives the Padres a 56% chance of defeating the Giants.

More: Giants vs. Padres Simulated 10,000 Times

Giants vs. Padres Game Odds

• Run Line: Padres -1.5 (+158), Giants +1.5 (-170)
• Moneyline: Padres -140, Giants +130
• Total: Over/Under 7.5 (+100/-114)

Run Line, Moneyline and Over/Under

The Padres are listed as -1.5 favorites against the Giants, with +158 at Caesars Sportsbook the best odds currently available.

For the underdog Giants (+1.5) to cover the run line, DraftKings Sportsbook has the best odds currently on offer at -170.

BetMGM currently has the best moneyline odds for the Padres at -140. That means you can risk $140 to win $100, for a total payout of $240, if they get the W.

Meanwhile, DraftKings Sportsbook currently has the best moneyline odds for the Giants at +130, where you can bet $100 to profit $130, earning a total payout of $230, if they win.

The Over/Under sits at 7.5 with BetMGM, which currently has the best odds for the Over at +100, while FanDuel Sportsbook currently has the best odds for the Under at -114.

As always, make sure you check the sportsbooks you can bet with in your state for the best MLB odds and lines.

According to DimersBOT, the Giants (+1.5) are a 62% chance of covering the run line, while the 7.5-run Over/Under is a 54% chance of going Over.

More: Best Bets for Every MLB Game

Best Bets for Giants vs. Padres

• Run Line: Padres -1.5 @ +158 via Caesars Sportsbook
• Moneyline: Giants @ +130 via DraftKings Sportsbook (0.5% edge)
• Total: Over 7.5 @ +100 via BetMGM (54% probability) 🔥

Every time you see a 🔥, you know it's one of Dimers' best bets of the day across all sports.

Dimers' best bets are based on detailed modeling and betting intelligence to bring you the best possible plays 24/7.

Even though the Giants are more likely to cover the run line, our best bet of Padres -1.5 is based on the chance of that happening, according to DimersBOT, and the best odds available.

And while the Padres are more likely to win the game, according to DimersBOT, taking the Giants moneyline is the best option due to the edge identified when comparing our data-led probabilities to the betting odds currently on offer.

Taking advantage of the edges published here at Dimers is one of the keys to being profitable in the long run.

Giants vs. Padres Prediction

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Dimers has full betting coverage of Tuesday's Giants-Padres matchup, including pregame predictions, free betting picks, and live win probabilities.

Remember, DimersBOT updates often, so check this page for any changes to our betting insights ahead of Giants vs. Padres on Tuesday October 4, 2022.

Giants vs. Padres 2022 Game Info

Tuesday's game between the Padres and Giants at PETCO Park is scheduled to start at 9:40PM ET.

• Who: San Francisco Giants vs. San Diego Padres
• Date: Tuesday October 4, 2022
• Time: 9:40PM ET / 6:40PM PT
• Venue: PETCO Park

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What MLB games are on today?

Now you've got the 411 on Giants vs. Padres, see the latest betting analysis for all upcoming MLB games in our MLB Bet Hub. There you can find probabilities and odds, and our best bets for each and every MLB matchup.

Want a pick for the Run Line? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!

While you're here, Dimers' Baseball Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities paired with the best odds available.