Giants vs. Diamondbacks Prediction and Odds - Sep 25, 2022

The Arizona Diamondbacks face the San Francisco Giants in MLB action at Chase Field on Sunday, beginning at 3:40PM ET.

The Diamondbacks will send Drey Jameson (2-0, 1.38 ERA) to the mound, pitting him against Scott Alexander (0-0, 1.38 ERA) for the Giants.

Dimers' best betting picks for Giants vs. Diamondbacks, as well as game predictions and best odds, are featured below.

Who will win Giants vs. Diamondbacks?

Based on state-of-the-art computer power and data, Dimers.com has simulated Sunday's Giants-Diamondbacks MLB matchup 10,000 times.

Dimers' revolutionary predictive analytics model, DimersBOT, currently gives the Diamondbacks a 56% chance of winning against the Giants.

More: Giants vs. Diamondbacks Simulated 10K Times

Giants vs. Diamondbacks Current Odds

• Run Line: Diamondbacks -1.5 (+170), Giants +1.5 (-188)
• Moneyline: Diamondbacks -125, Giants +112
• Total: Over/Under 8 (-110/-108)

Run Line, Moneyline and Over/Under

The Diamondbacks are listed as -1.5 favorites against the Giants, with +170 at DraftKings Sportsbook the best odds currently available.

For the underdog Giants (+1.5) to cover the run line, FanDuel Sportsbook has the best odds currently on offer at -188.

BetMGM currently has the best moneyline odds for the Diamondbacks at -125. That means you can risk $125 to win $100, for a total payout of $225, if they get the W.

Elsewhere, FanDuel Sportsbook currently has the best moneyline odds for the Giants at +112, where you can put down $100 to profit $112, earning a total payout of $212, if they win.

The Over/Under for total runs scored is set at 8 with Caesars Sportsbook, which currently has the best odds for the Over at -110, while FanDuel Sportsbook currently has the best odds for the Under at -108.

As always, check out the sportsbooks you can bet with in your state for the best MLB odds and lines.

According to DimersBOT, the Giants (+1.5) are a 62% chance of covering the run line, while the Over/Under total of 8 runs is a 55% chance of going Over.

More: Free Online Bet Tracker

Best Bets for Giants vs. Diamondbacks

• Run Line: Diamondbacks -1.5 @ +170 via DraftKings Sportsbook (1.4% edge)
• Moneyline: Diamondbacks @ -125 via BetMGM (56% probability)
• Total: Over 8 @ -110 via Caesars Sportsbook (55% probability)

Dimers' best bets are based on complex modeling and wagering intelligence to bring you the best possible plays every time.

Although the Giants are more likely to cover the run line, our best bet of Diamondbacks -1.5 is based on the likelihood of that happening, according to DimersBOT, and the best odds available.

Giants vs. Diamondbacks Prediction

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Dimers has full coverage of Sunday's Giants-Diamondbacks matchup, including pregame predictions, computer picks, and live win probabilities.

Don't forget, DimersBOT updates often, so refresh this article for any changes to our betting analysis ahead of Giants vs. Diamondbacks on Sunday September 25, 2022.

Giants vs. Diamondbacks 2022 Game Info

Sunday's game between the Diamondbacks and Giants at Chase Field is scheduled to start at 3:40PM ET.

• Who: San Francisco Giants vs. Arizona Diamondbacks
• Date: Sunday September 25, 2022
• Time: 3:40PM ET / 12:40PM PT
• Venue: Chase Field

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What MLB games are on today?

The Giants and Diamondbacks aren't the only two MLB teams you can bet on today. DimersBOT never stops and we've got picks and best bets for each and every MLB matchup in our MLB Bet Hub section.

Not only do we provide with you top-notch predictions, but we also have recommended bets for the Run Line, Over/Under and Moneyline. Sound good? Hell yeah it does!

While you're here, Dimers' Baseball Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities matched against the best odds to win the World Series.