Giants vs. Bills Week 6 Prediction and Odds - October 15, 2023

NFL Week 6 action continues on Sunday at 8:20PM ET as the New York Giants look to defy the odds against the Buffalo Bills at Highmark Stadium.

Dimers' best betting picks for Giants vs. Bills, as well as game predictions, betting odds and touchdown scorer probabilities, are detailed in this article.

This NY Giants vs. Buffalo betting analysis is proudly sponsored by Bet365, which has a tasty Bet $5, Get $150 in Bonus Bets promo for new customers.

Who Will Win: Giants vs. Bills

Using trusted machine learning and data, Dimers.com has simulated Sunday's Giants-Bills NFL game 10,000 times.

Dimers' revolutionary predictive analytics model, DimersBOT, currently gives the Bills a 93% chance of beating the Giants in Week 6 of the NFL season.

More: Giants vs. Bills Simulated 10K Times

Giants vs. Bills Odds

• Spread: Bills -15.5 (-110), Giants +15.5 (-105)
• Moneyline: Bills -1099, Giants +830
• Total: Over/Under 43.5 (-110/-105)

The Bills are listed as -15.5 favorites against the Giants, with -110 at DraftKings Sportsbook the best odds currently available.

For the underdog Giants (+15.5) to cover the spread, FanDuel Sportsbook has the best odds currently on offer at -105.

PointsBet currently has the best moneyline odds for the Bills at -1099, which means you can risk $1,099 to win $100, for a total payout of $1,199, if they get the W.

Elsewhere, FanDuel Sportsbook currently has the best moneyline odds for the Giants at +830, where you can bet $100 to profit $830, earning a total payout of $930, if they win.

The Over/Under for total points scored is set at 43.5 with DraftKings Sportsbook, which currently has the best odds for the Over at -110, while FanDuel Sportsbook currently has the best odds for the Under at -105.

As always, check out all the legal sportbooks that are available in your state for the best NFL odds and lines.

According to DimersBOT, the Giants (+15.5) have a 52% chance of covering the spread, while the 43.5-point Over/Under has a 54% chance of going Under.

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More: Predictions for Every NFL Week 6 Game

Best Bets: Giants vs. Bills

• Spread: Giants +15.5 @ -105 via FanDuel Sportsbook (52% probability)
• Moneyline: Bills @ -1099 via PointsBet (93% probability)
• Total: Under 43.5 @ -105 via FanDuel Sportsbook (54% probability)

Our best bets are based on detailed simulations and betting intelligence to help you make better decisions with your state's legal sportsbooks.

Giants vs. Bills Prediction

Dimers.com's predicted final score for NY Giants vs. Buffalo at Highmark Stadium in Week 6 has the Bills winning 28-13.

Click or tap on See Matchup for more information.

Dimers has full betting coverage of this week's Giants-Bills game in Week 6, including pregame predictions, free picks, and live win probabilities.

Giants vs. Bills Player Props

Who will score the first touchdown in Giants vs. Bills? The data is in.

Featured below are the most likely first touchdown and most likely anytime touchdown scorers for both the Giants and Bills, as well as player stat projections.

And you know what, we provide this information to you for FREE to help you discover the best prop bets for Sunday's game.

According to DimersBOT, Buffalo's Stefon Diggs is most likely to score the first TD in Giants vs. Bills.

DimersBOT gives Diggs a 13.6% chance of scoring the first TD at Highmark Stadium, while the Bills WR is a 51.8% chance of registering an anytime touchdown.

Scroll down for our complete list of first and anytime TD scorer probabilities, which provide a great avenue for you to use this DraftKings Sportsbook offer, which unlocks $200 in bonus bets from a $5 bet on any of the below players.

First Touchdown Scorer Probabilities

New York Giants

• Saquon Barkley: 9.2% probability
• Wan'Dale Robinson: 4.6% probability
• Darren Waller: 4.5% probability
• Darius Slayton: 3.2% probability
• Tyrod Taylor: 2.1% probability

Buffalo Bills

• Stefon Diggs: 13.6% probability
• James Cook: 11.7% probability
• Gabe Davis: 10.8% probability
• Josh Allen: 9.0% probability
• Dawson Knox: 6.4% probability

Anytime Touchdown Scorer Probabilities

New York Giants

• Saquon Barkley: 42.4% probability
• Darren Waller: 22.4% probability
• Wan'Dale Robinson: 21.9% probability
• Darius Slayton: 16.3% probability
• Tyrod Taylor: 11.4% probability

Buffalo Bills

• Stefon Diggs: 51.8% probability
• James Cook: 47.0% probability
• Gabe Davis: 43.7% probability
• Josh Allen: 37.2% probability
• Dawson Knox: 28.4% probability

Giants-Bills Projected Player Stats

Of the starting quarterbacks, the Giants' Tyrod Taylor is projected to have a quiet game with 168 passing yards, while the Bills' Josh Allen is expected to throw for 251 yards.

Giants Starting QB

• Tyrod Taylor: 168 projected yards

Bills Starting QB

• Josh Allen: 251 projected yards

Giants Rushing

• Saquon Barkley: 59 projected yards
• Tyrod Taylor: 21 projected yards
• Eric Gray: 14 projected yards

Bills Rushing

• James Cook: 61 projected yards
• Josh Allen: 28 projected yards
• Damien Harris: 24 projected yards

Giants Receiving

• Wan'Dale Robinson: 44 projected yards
• Darren Waller: 43 projected yards
• Darius Slayton: 33 projected yards
• Parris Campbell: 19 projected yards
• Isaiah Hodgins: 18 projected yards

Bills Receiving

• Stefon Diggs: 90 projected yards
• Gabe Davis: 75 projected yards
• Dawson Knox: 36 projected yards
• Deonte Harty: 21 projected yards
• Trent Sherfield: 16 projected yards

Remember, DimersBOT updates regularly, so keep checking this page for the latest betting analysis before Giants vs. Bills on Sunday October 15, 2023.

Giants vs. Bills 2023

The NFL Week 6 matchup between the Bills and Giants at Highmark Stadium is scheduled to begin at 8:20PM ET.

• Who: New York Giants vs. Buffalo Bills
• Date: Sunday October 15, 2023
• Time: 8:20PM ET / 5:20PM PT
• Venue: Highmark Stadium

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Make Smarter Sports Betting Decisions with Dimers

Dimers' picks and predictions are based on 10,000 simulations per game, using reliable and up-to-date data sources and analytical methods.

While our Giants vs. Bills predictions can help you make informed decisions, it's crucial that you only bet what you can afford to lose and manage your bankroll effectively.

For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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So, you liked our Giants vs. Bills betting analysis? Awesome. Did you know our NFL Betting News page has a comprehensive betting preview for every NFL game as soon as the sportsbooks put out their odds?

That's right, our predictive analytics model then compares those odds against its own probabilities to find value in the markets. This allows us to create the most reliable NFL betting previews and beat the public and the sportsbooks to the punch.

In addition to our leading NFL predictions, we also feature the best NFL prop bets today, projecting passing yards, touchdowns, and more against the top odds available every single day of the NFL season.