Flavio Cobolli vs. Holger Rune Prediction, Odds, Picks for ATP Madrid Open 2025

Flavio Cobolli will square off with Holger Rune in the round of 64 at the ATP Madrid event on Friday.

Based on the latest simulation results, Dimers' advanced tennis model (see Dimers Pro for full access) predicts Holger Rune as the most likely winner of the match.

"Employing the latest data, we simulated Friday's Cobolli-Rune match 10,000 times," said Dimers data analyst Greg Butyn.

"After computing the latest updates and thousands of other inputs, we predict Holger Rune's chance of winning is 62%, while Flavio Cobolli's is 38%."

For a closer look at Friday's match, including best bets and picks, visit our interactive Cobolli vs. Rune predictions page.

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Cobolli vs. Rune Prediction: Who Will Win and Advance to the Round of 32?

Using innovative machine learning and data analysis, we have simulated the result of Friday's Cobolli-Rune men's singles match 10,000 times as part of our tennis predictions coverage.

Our independent predictive model gives Rune a 62% chance of defeating Cobolli at the ATP Madrid Open tournament.

Additionally, Rune has a 59% chance of winning the first set, according to our model.

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Flavio Cobolli vs. Holger Rune Odds

We have sourced the most up-to-date betting odds in America for this match, which are listed here:

All odds are correct at the time of publication and are subject to change.

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Cobolli vs. Rune Picks and Best Bets

Our model's biggest edge in today's Cobolli vs. Rune match is on the moneyline.

Our expert predictions, aligned with the latest odds, reveal the best tennis picks and tennis best bets for every tournament throughout the year.

Unlimited access to our complete set of picks, including this one, is available via Dimers Pro.

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Cobolli vs. Rune Updates and Essential Details

The ATP Madrid Open match between Flavio Cobolli and Holger Rune is scheduled to commence on Friday at 2:10PM ET.

• Who: Flavio Cobolli vs. Holger Rune
• Date: Friday, April 25, 2025
• Approx. Time: 2:10PM ET/11:10AM PT
• Tournament: ATP Madrid, Spain Men's Singles 2025
• Round: Round of 64

All dates and times mentioned in this article are United States Eastern Time unless otherwise noted.

Dimers.com's comprehensive preview of Friday's Cobolli vs. Rune match includes our prediction, picks and the latest betting odds.

Before making any Flavio Cobolli vs. Holger Rune picks, be sure to check out the latest tennis predictions and betting advice from Dimers Pro.

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Conclusion

We predict Holger Rune, with a 62% win probability, will likely beat Flavio Cobolli at the ATP Madrid Open tournament.

AI and automation have enhanced this article to quickly deliver accurate Cobolli vs. Rune insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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