Duke vs. Louisville CFB Prediction and Odds - October 28, 2023

Louisville and Duke clash in College Football action at L&N Federal Credit Union Stadium on Saturday, beginning at 3:30PM ET.

Dimers' prediction for Saturday's Duke vs. Louisville matchup, plus the latest odds and our comprehensive game preview, are featured below.

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Who Will Win: Duke vs. Louisville

Using trusted computer power and data, Dimers.com has simulated the outcome of Duke vs. Louisville 10,000 times.

Dimers' popular predictive analytics model, DimersBOT, currently gives Louisville a 59% chance of beating Duke.

More: Duke vs. Louisville Simulated 10,000 Times

Duke vs. Louisville Odds

We have researched the best betting odds in America for this game, which are listed here:

• Spread: Louisville -4.5 (-112), Duke +4.5 (-108)
• Moneyline: Louisville -194, Duke +175
• Total: Over/Under 47 (-110/-110)

Odds are correct at the time of publication and subject to change.

Louisville is the -4.5 favorite against Duke, with -112 at FanDuel Sportsbook the best odds currently available.

For the underdog Duke (+4.5) to cover the spread, FanDuel Sportsbook also has the best odds currently on offer at -108.

FanDuel Sportsbook currently has the best moneyline odds for Louisville at -194. That means you can risk $194 to win $100, for a total payout of $294, if it gets the W.

Meanwhile, PointsBet currently has the best moneyline odds for Duke at +175, where you can bet $100 to profit $175, earning a total payout of $275, if it wins.

The Over/Under is set at 47 with PointsBet, which currently has the best odds for the Over at -110, as well as the best odds for the Under at -110.

As always, check out the sportsbooks you can bet with in your state for the best College Football odds and lines.

According to DimersBOT, Duke (+4.5) has a 54% chance of covering the spread, while the 47-point Over/Under has a 52% chance of going Under.

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More: Best Prop Bets to Make Today

Best Bets: Duke vs. Louisville

• Spread: Duke +4.5 @ -108 via FanDuel Sportsbook (54% probability)
• Moneyline: Duke @ +175 via PointsBet (4.5% edge) 🔥
• Total: Under 47 @ -110 via PointsBet (52% probability)

If you see a 🔥, you know you've found one of our best free picks of the day across any sport.

Our best bets are based on complex simulations and gambling expertise to help you make more informed decisions with your state's legal sportsbooks.

While Louisville is more likely to win the game, according to DimersBOT, betting on Duke moneyline is the best option because of the 4.5% edge identified when comparing our data-led probabilities to the betting odds currently on offer.

Taking advantage of the edges published here at Dimers.com is pivotal to achieving long-term profitability as a sports bettor.

Duke vs. Louisville Prediction

Dimers.com's predicted final score for Duke vs. Louisville at L&N Federal Credit Union Stadium on Saturday has Louisville winning 24-21.

Click or tap on See Matchup for more information.

Dimers has full betting coverage of this week's Duke vs. Louisville game, including pregame predictions, the best picks, and live win probabilities.

Remember, DimersBOT updates often, so check this article for any changes to our betting insights before Duke vs. Louisville on Saturday October 28, 2023.

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Duke vs. Louisville Preview

Saturday's matchup between Louisville and Duke in College Football at L&N Federal Credit Union Stadium is scheduled to commence at 3:30PM ET.

• Who: Duke vs. Louisville
• Date: Saturday October 28, 2023
• Time: 3:30PM ET / 12:30PM PT
• Venue: L&N Federal Credit Union Stadium

How to Bet on Duke vs. Louisville

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Conclusion

This comprehensive game preview includes our Duke vs. Louisville prediction and College Football odds.

Dimers' picks and predictions are based on 10,000 simulations per game, using reliable and up-to-date data sources and analytical methods.

While these Duke vs. Louisville picks can help you make informed decisions, it's vital that you gamble responsibly and manage your bankroll effectively.

To increase your ability to be a responsible gambler, we recommended looking into this full guide to Kentucky sports betting as well as utilizing these .Kentucky sportsbook promos that can get you started off on the right foot.

For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

What Other CFB Games Are on This Week?

Duke and Louisville aren't the only two NCAA Football teams you can bet on today. DimersBOT never stops and we've got picks and top bets for every single CFB game via our College Football predictions. Not only do we provide with you first-class predictions, but we also have recommended bets for the Spread, Over/Under and Moneyline. Sound good? Check it out now!

In addition to our leading CFB predictions, Dimers also offers the best CFB prop bets today, projecting passing yards, touchdowns, and more against the best odds available every single day of the CFB season.